Of the total sample, Sheehan's syndrome (n=15) were all women, tuberculoma of pituitary gland were also found in women only (n=2), out of 10 patients having empty sella
syndrome, seven were women, hypoplastic pituitary gland was found in two women and one man.
Bromocriptine was prescribed in 17 (17.5%) patients, of these 15 had Prolactinoma; 1 patient had Acromegaly and 1 had Empty sella
Regarding subheadings, there was moderate agreement for empty sella
(Figure 1), tortuosity of the optic nerve (Figure 1) and nonspecific white matter lesions ([kappa] = 0.417, p=0.001; [kappa] = 0.523, p=0.001; [kappa] = 0.443, p=0.002, respectively), fair agreement for flattened posterior globe/sclera and transverse venous sinus stenosis (Figure 2) ([kappa] = 0.291, p=0.06; [kappa]=0.389, p=0.006, respectively), and substantial agreement for transverse venous sinus hypoplasia ([kappa]=0.801, p<0.001) (Table 1).
Cerebral MRI showed empty sella
and distension of the perioptic subarachnoid space in 57% and 65% of cases, respectively (Figure 1).
Furthermore, thickening of the pituitary stalk with loss of neurohypophysis bright spot and partially empty sella
was noted on the initial MRI; however, no clinical manifestations of DI or hormonal disturbances were apparent as reported in literature.
Adenomas were found in nine (10%) and empty sellas
in seven (8%).
in children and adolescents with possible hypothalamic-pituitary disorders.
MRI brain of the patient was done on follow up, which revealed an empty sella
12(7%) cases of complete/partial empty sella
syndrome were seen.
It develops from bilateral involvement of the uncrossed fibers at the chiasma such as bilateral internal carotid artery atherosclerosis or aneurysm, olfactory groove meningioma, empty sella
syndrome, chronic raised intracranial pressure, and neurosyphilis affecting both optic nerves.
Whereas the only female was 38 years old tall, obese, with a history of headache and an associated empty sella
. She had spontaneous CSF rhinorrhoea and high BMI which has been associated with spontaneous leaks in other studies.11
The medial aspect of the temporal bone may fail to develop, resulting in a persistent lateral craniopharyngeal canal (also known as the Sternberg canal) between the middle cranial fossa and the pneumatised inferolateral recess of the sphenoid sinus.3 Idiopathic intracranial hypertension (pseudotumour cerebri) and empty sella
syndrome are also known to occur in these patients,2 suggesting that chronically increased intracranial pressure with localised thinning of the bone may also play a role in the pathogenesis of this condition.4