emetine


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emetine

 [em´ĕ-tēn]
an alkaloid derived from ipecac or produced synthetically; its hydrochloride salt is used as an antiamebic.

em·e·tine

(em'ĕ-tēn),
The principal alkaloid of ipecac, used as an emetic; its salts are used in amebiasis; available as the hydrochloride.

emetine

(ĕm′ĭ-tēn′)
n.
A bitter-tasting crystalline alkaloid, C29H40N2O4, derived from ipecac root and used in the treatment of amebiasis and as an emetic.

em·e·tine

(em'ĕ-tēn)
The principal alkaloid of ipecachuana (q.v.); used as an emetic; its salts are used in amebiasis; available as the hydrochloride.

emetine

An alkaloid derived from ipecacuanha sometimes used in the treatment of AMOEBIASIS. It has now been largely replaced by the safer METRONIDAZOLE.

em·e·tine

(em'ĕ-tēn)
The principal alkaloid of ipecac, used as an emetic.
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28.7 [+ or -] 8.8 (Padmaja, R., et al, 2002)] (b) Emetine hydrochloride (c) nd; 20.1 [+ or -] 0.2 (Wanyoike, G.N., et al., 2004) (b) Cyclophosphamide (c) nd;16.3 [+ or -] 6.0 (Moshi, M.J., et al, 2004) (b) nd: not determined; (a) [LC.sub.50] is the lethal concentration of extract at which 50% mortality (lethality) of brine shrimp nauplii was observed; (b) mentioned [LC.sub.50] values for Acorus calamus, piperine and reference standards (Emetine HCl and Cyclophosphamide) have been taken from literature; (c) positive standards.
Production of the alkaloids emetine and cephaeline in callus cultures of Cephaelis ipecacuanha.
Must be the massive doses of sulfa, emetine, arsenic, 3,000,000 units of penicillin, and all the bismuth.
Emetine, the ingredient that triggers the vomit reflex, attaches to the heart muscle, where it can cause cardiac arrest.
Once the rate of protein synthesis (described above) was obtained, an inhibitor of protein synthesis (emetine) was used.
Plants are reported to have antimicrobial agents such as emetine quinine and berberine tannins terpenoids alkaloids and falvonoids (Marjorie 1999).
(6) Some significant examples from this group of natural products include the analgesic morphine from Papaver somniferum L., the anti-gout colchicine from Colchicum autumnale L., the emetic and antiamoebic emetine from Cephaelis ipecacuanha (Brot.) A.
We took a two-fold approach in which the effect of high pC[O.sub.2] was first tested on the dark respiration of coral recruits exposed to emetine to inhibit protein synthesis (Fenteany and Morse, 1993; Pace and Manahan, 2006).
The alkaloid emetine as a promising agent for the induction and enhancement of drug-induced apoptosis in leukemia cells.
neumayeri were conducted by quantifying the difference in protein synthesis and oxygen consumption rates in the presence and absence of the inhibitors anisomycin and emetine (Sigma Chemical Co.).
Success stories include the treatment of malaria and amoebiasis using the alkaloids, quinine and emetine obtained from Cinchona and Cephalis, respectively; in more recent times, Artemisinin, a sesquiterpene lactone derived from the herb Artemisia annua has been an invaluable addition (Golenser et al.