2008; Poroikov and Filimonov 2005; Borodina et al 2003; Stepanchikova, Lagunin, Filimonov and Poroikov, 2003), which predicts about 2500 pharmacological effects, mechanisms of action, mutagenicity, carcinogenicity, teratogenicity and embryotoxicity
on the basis of structural formulae of compounds.
In chronic experiments the parameters of chronic toxicity and embryotoxicity
of compounds in a single seeding of the parental generation (P) and the constant seeding of Daphnia in a number of generations (P-F1-F2-F3) were determined in terms of "survival" and "fertility".
This will enable standardized, fast and efficient embryotoxicity
screenings reducing the need for animal tests.
Methanol, formaldehyde, and sodium formate exposure in rat and mouse conceptuses: A potential role of the visceral yolk sac in embryotoxicity
of the artemisinin antimalarials and potential consequences for use in women in the first trimester.
assay of aflatoxin produced by Aspergillus parasiticus NRRL 2999.
The Center has established technologies for reproductive toxicity including fertility studies, embryotoxicity
, teratogenecity, postnatal developmental toxicity and genetic toxicity including tests for detection of chromosomal aberrations.
Plants with estrogenic activity produces embryotoxicity
, and sex-related differences in toxicity (MARUO et al.
310) Other scientifically validated in vitro tests, such as tests for skin corrosivity and embryotoxicity
, also generate data that can be usefully extrapolated to in vivo exposure and should be required.
It's been suggested that gels containing chlorhexidine may reduce the risk of infection, but concerns have been raised about embryotoxicity
in younger women.
Effect of pentoxifylline in reducing oxidative stress-induced embryotoxicity
Inhibiting alcohol metabolism (thereby increasing circulating alcohol levels and consequent fetal exposure) in pregnant mice increased the embryotoxicity
of alcohol, suggesting that alcohol, rather than its metabolites, is responsible for its toxicity (Ukita et al.