Scientists at Eidgenossische Technische Hochschule Zurich (ETH Zurich) in Basel have now developed a test that allows them to examine a drug's embryotoxicity
in cell cultures instead of animals.
The drug caused embryotoxicity
, fetotoxicity, and teratogenicity in rats and rabbits at doses less than the human dose.
The zebrafish embryotoxicity
test (ZET) was used to assess the potential effects of petroleum substances on prenatal development by Lenny Kamelia and colleagues.
Cadmium potentially can cause serious environmental hazards including embryotoxicity
, carcinogenicity and teratogenicity in developing embryos, which may lead to the serious abnormalities such as reduction in body weight, micromelia, micropthelmia and hemorrhages (Gilani and Alibhai, 1990).
Evaluation of embryotoxicity
using the zebrafish model.
"Some drugs are difficult for doctors to prescribe to pregnant women because they don't know the embryotoxicity
, how does that affect fetal development," said researcher Zhen Ma.
suffruticosa extracts at varying doses (250-1000 mg/ml) in models for embryotoxicity
in the development and oviposition of Aedes aegypti.
Di Giulio, "Synergistic embryotoxicity
of polycyclic aromatic hydrocarbon aryl hydrocarbon receptor agonists with cytochrome P4501A inhibitors in Fundulus heteroclitus," Environmental health perspectives, vol.
Niapour, Study of embryotoxicity
of Perovskia abrotanoides, an adulterant in folk medicine during organogenesis in mice, Journal of Ethnopharmacology, 117, 108 (2008).
of cobalt ferrite and gold nanoparticles: a first in vitro approach.
On the other hand, favipiravir has a risk for teratogenicity and embryotoxicity
. Therefore, the Ministry of Health, Labor and Welfare granted conditional marketing approval with strict regulations for its production and clinical use.
Alternatively, angiogenesis is not as important in RIF as it is in RM and maternal immune-mediated embryotoxicity
, possibly via activated NK cells (44) or raised Th1 type immunity (45) being a more important factor.