embryotoxicity

embryotoxicity

 [em″bre-o-tok-sis´ĭ-te]
toxic effects on the embryo of a substance that crosses the placental barrier; see also embryolethality and teratogenesis. adj. adj embryotox´ic.

em·bry·o·tox·ic·i·ty

(em'brē-ō-tok-sis'i-tē),
Injury to the embryo, which may result in death, growth retardation, or abnormal development of a part that may affect either its structure or function.

embryotoxicity

Toxicology Adverse effects on the embryo due to a substance that enters the maternal system and crosses the placental barrier; the effects of the substance may be expressed as embryonic death  or abnormal development of one or more body systems, and can be deleterious to maternal health. Cf Fetotoxicity.

em·bry·o·tox·ic·i·ty

(em'brē-ō-tok-sis'i-tē)
Injury to the embryo, which may result in death or abnormal development of a part, owing to substances that enter the placental circulation.
References in periodicals archive ?
Scientists at Eidgenossische Technische Hochschule Zurich (ETH Zurich) in Basel have now developed a test that allows them to examine a drug's embryotoxicity in cell cultures instead of animals.
The drug caused embryotoxicity, fetotoxicity, and teratogenicity in rats and rabbits at doses less than the human dose.
The zebrafish embryotoxicity test (ZET) was used to assess the potential effects of petroleum substances on prenatal development by Lenny Kamelia and colleagues.
Cadmium potentially can cause serious environmental hazards including embryotoxicity, carcinogenicity and teratogenicity in developing embryos, which may lead to the serious abnormalities such as reduction in body weight, micromelia, micropthelmia and hemorrhages (Gilani and Alibhai, 1990).
"Some drugs are difficult for doctors to prescribe to pregnant women because they don't know the embryotoxicity, how does that affect fetal development," said researcher Zhen Ma.
suffruticosa extracts at varying doses (250-1000 mg/ml) in models for embryotoxicity in the development and oviposition of Aedes aegypti.
Di Giulio, "Synergistic embryotoxicity of polycyclic aromatic hydrocarbon aryl hydrocarbon receptor agonists with cytochrome P4501A inhibitors in Fundulus heteroclitus," Environmental health perspectives, vol.
Niapour, Study of embryotoxicity of Perovskia abrotanoides, an adulterant in folk medicine during organogenesis in mice, Journal of Ethnopharmacology, 117, 108 (2008).
On the other hand, favipiravir has a risk for teratogenicity and embryotoxicity. Therefore, the Ministry of Health, Labor and Welfare granted conditional marketing approval with strict regulations for its production and clinical use.
Alternatively, angiogenesis is not as important in RIF as it is in RM and maternal immune-mediated embryotoxicity, possibly via activated NK cells (44) or raised Th1 type immunity (45) being a more important factor.