Amplification and overexpression of MDM2, CDK4, GL1 and SAS genes of the 12q13-15 region has been associated with other sarcomas such as well-differentiated and dedifferentiated liposarcoma, leiomyosarcoma, and a significant subset of alveolar and embryonal rhabdomyosarcomas  and even sclerosing epithelioid fibrosarcoma .
In a subsequent series of four additional cases, Folpe considered these tumors to be either highly unusual variants of adult embryonal rhabdomyosarcoma or an entirely novel subcategory of rhabdomyosarcoma .
Sciot, "Adult sclerosing rhabdomyosarcoma: cytogenetic link with embryonal rhabdomyosarcoma," Virchows Archiv, vol.
Pazzaglia et al., "Amplification of CDK4, MDM2, SAS and GLI genes in leiomyosarcoma, alveolar and embryonal rhabdomyosarcoma," Histology and Histopathology, vol.
Sukov and coworkers (11) found ALK gene rearrangements in 67% of tumors in a series that included 21 cases of IMTs of the urinary bladder, but found no such ALK gene rearrangement in the other tumors among 32 non-IMTs tested, including 16 leiomyosarcomas and 3 embryonal rhabdomyosarcomas
. Li and coworkers (12) studied 249 soft tissue tumors and found only IMTs (2 of 3 cases; 75%) to contain ALK gene rearrangements by FISH, and whereas 4 non-IMTs, including 2 leiomyosarcomas, 1 rhabdomyosarcoma, and 1 malignant fibrous histiocytoma, demonstrated ALK gene amplification, no non-IMTs had rearrangements of the ALK gene.
Microscopically, embryonal rhabdomyosarcomas are pleomorphic.
The author reports a case of embryonal rhabdomyosarcoma of the temporal bone with cranial nerve palsies and extension into the parapharyngeal space in a 4-year-old boy.
Prat and Gray reviewed the presenting signs and symptoms in 50 patients with embryonal rhabdomyosarcoma reported by various authors.
Embryonal rhabdomyosarcoma. Indian J Otolaryngol 1987;39:125-6.