There are several prevailing theories of the pathophysiology of endometriotic lesions which include the coelomic metaplasia theory, the embryonal rest
theory, and the retrograde menstruation theory .
These tumors may result from metaplasia of fibroblasts, be derived from primitive mesenchymal cells, or possibly arise from embryonal rests
of the cartilaginous matrix within the bone.
Chondrosarcomas arise from either chondrocytes, embryonal rests
, or mesenchymal cells that undergo multidirectional differentiation.