Few data exist regarding the use of ribavirin in pregnant humans; however, the drug is generally contraindicated in pregnancy (14,15) because of evidence of teratogenic and embryocidal
effects in animal studies.
teratogenic and fetotoxic effects of citrinin in rats.
Teratogenicity and embryocidal
effects of zidovudine in mice.
and larvicidal effects of triflumuron against the red flour beetle, Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae).
However, the drug is teratogenic and embryocidal
in animals at low doses, and mutagenic in some assays.
Ribavirin is associated with teratogenic and embryocidal
effects, and is contraindicated in women who are pregnant and in male partners of women who are pregnant.
C: Either animal studies have revealed adverse effects on the fetus (teratogenic or embryocidal
or other) and there are no controlled studies in women, or studies in women and animals are not available.
It is not teratogenic in rats and rabbits, but is embryocidal
Labeled as pregnancy category X because of significant teratogenic and/or embryocidal
effects of Rebetol in animal species.
It appears that thus far, B19 infection during pregnancy can be embryocidal
, not teratogenic (AAP, 1990).
The drugs previously were classified as category C, meaning that a drug had been shown to be teratogenic or to have embryocidal
effects in animals, but that there are no human data.
The combination agent imipenem-dilastatin (Primaxin), rated C, is not teratogenic in animals but was embryocidal
and lethal in pregnant monkeys at about three times the recommended human dose.