elliptocytosis


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elliptocytosis

 [e-lip″to-si-to´sis]
any of several hereditary disorders in which most of the erythrocytes are elliptocytes; it is characterized by increased erythrocyte destruction and anemia.

el·lip·to·cy·to·sis

(ē-lip'tō-sī-tō'sis),
A hematologic disorder in which 50-90% of the red blood cells consist of rod forms and elliptocytes; often associated with a hemolytic anemia. There are several autosomal dominant forms [MIM*130500, MIM*130600, and MIM*179650], with one form linked to the Rh blood group, caused by mutation in the gene encoding erythrocyte membrane protein band 4.1 (EPB41) on chromosome 1p, whereas the unlinked form is due to mutation either in the alpha-spectrin gene on 1q, or in the beta-spectrin gene on 14q or the band 3 gene on 17q. There is one autosomal recessive form [MIM*225450] known.
Synonym(s): ovalocytosis

elliptocytosis

/el·lip·to·cy·to·sis/ (e-lip″to-si-to´sis) a hereditary disorder characterized by elliptocytes, with increased red cell destruction and anemia.

elliptocytosis

[ilip′tōsītō′sis]
Etymology: Gk, elleipsis + kytos + osis, condition
an abnormal condition of the blood characterized by increased numbers of elliptocytes. Less than 15% of the red blood cells appear in this form in normal blood; modest increases occur in a variety of anemias, including a rare congenital disorder, hereditary elliptocytosis. Also called ovalocytosis. Compare spherocytosis. See also acanthocytosis, congenital nonspherocytic hemolytic anemia, sickle cell anemia, spherocytic anemia.

el·lip·to·cy·to·sis

(ē-lip'tō-sī-tō'sis)
A hereditary abnormality of hemopoiesis in which 50-90% of the red blood cells consist of rod forms and elliptocytes, often with an associated hemolytic anemia.
Synonym(s): ovalocytosis.

elliptocytosis

Oval-shaped red blood cells. A small proportion of oval cells occurs in MEGALOBLASTIC ANAEMIA and HYPOCHROMIC ANAEMIA. A high proportion suggests an unimportant dominant hereditary disorder.

el·lip·to·cy·to·sis

(ē-lip'tō-sī-tō'sis)
A hereditary abnormality of hemopoiesis in which 50-90% of the red blood cells consist of rod forms and elliptocytes.
Synonym(s): ovalocytosis.

elliptocytosis (ēlip´tōsītō´sis),

n (ovalcytosis, oval cell anemia), a hereditary anomaly in which the red blood cells are elliptical, or oval shaped, and are predisposed to hemolysis.
References in periodicals archive ?
Other acquired causes of elliptocytosis should be investigated which include iron deficiency anaemia, folate or B12 deficiency, thalassaemia, etc.
However, as the morphometric characteristics of inorganic cells are homeomorphic to the ones of normal blood cells (morphometric characteristic of elliptocytosis is an affine transformation of the morphometric characteristic of normal erythrocytes, while stomatocytosis in this transformation takes place only in its central zone), the nature of initiation is not clear.
Additional non-cellular therapies for severe and refractory anemias, including spherocytosis, elliptocytosis, and pyruvate kinase deficiency, may include partial or total splenectomy or bone marrow transplantation (Altman, 2002).
These particles include red cell fragments, microspherocytes, nucleated RBCs, nonlyzed RBCs, elliptocytosis, macrothrombocytes, platelet clumps, bacteria, parasitic organisms, and other interfering substances such as cryoglobulin, cold agglutinin, and macroglobinemia.
In addition, it will be important to test the use of this device for transport of samples from patients with hematological disorders that affect the erythrocyte, such as hereditary elliptocytosis (18), sickle cell anemia, hypochromic anemia, and hereditary spherocytosis (19).