The 10 class labels chosen were based on clinical significance and availability: schistocytes, dacrocytes (teardrop cells), acanthocytes, elliptocytes
, stomatocytes, spherocytes, codocytes (target cells), echinocytes, overlap, and normal.
It should be noted that the classic morphologic abnormalities of HE (elliptocytes
) are usually not present during the first few weeks of life.
The college student presented to the physician's office with a critical hemoglobin, microcytic/hypochromic red blood cells with a few elliptocytes
, a high RDW, and thrombocytosis.
Pencil cells Iron deficiency Stomatocytes Artifact (due to slow drying in humid environment), Liver disease, alcoholism, Rh-null disease, Obstructive lung disease Elliptocytes
Hereditary Elliptocytosis (>25%) Bite cells (degmacytes) G6PD deficiency, Oxidative stress, unstable haemoglobins, congenital heinz body anaemia Basket cells (half ghost Oxidant damage, G6PD deficiency, cells/Blister cells) Unstable haemoglobins Spherocytes Hereditary spherocytosis, ABO incompatibility, Autoimmune hemolytic anemia (warm antibody type), Severe burns Teardrop red cell Idiopathic myelofibrosis, (dacrocytes, myelophthisic anaemia, lacrymocytes) thalassemias
RBCs with abnormal shapes (e.g., spherocytes or elliptocytes
) or sizes (e.g., microcytes or macrocytes) may not remain active in the bloodstream for the full 120 days, but may become sequestered and destroyed earlier.
Neutrophil Changes Erythrocyte Changes Cytoplasmic vacuoles Crenated (burr cells, echinocytes) Loss of granulations Spherocytes Elongated nuclei Elongated (elliptocytes
) (loss of segmentation) Undefined chromatin Schistocytes (fragments) (appear liquefied) Pyknotic nuclei (necrobiotic) Hypochromic Cytoplasm rupture Smudge (basket) cells
Peripheral blood smear findings described in the erythroid line in MDS include spherocytes, macroovalocytes, acanthocytes, elliptocytes
, stomatocytes, teardrop cells, nucleated erythrocytes, basophilic stippling, and howell-jolly bodies.
Blood films showed a normochromic picture with irregularly shaped cells, elliptocytes
, and erythrocyte fragments suggestive of an erythrocyte membrane defect.
(5.) Rodgers MS, Cheng C, Kass L Elliptocytes
and tailed poikilocytes correlate with severity of iron-deficiency anemia.
RBC membrane defects ([greater than]10% of any individual poikilocyte not listed above; e.g., spherocytes, elliptocytes
We've eliminated "occ'l" when describing elliptocytes
, target cells, burr cells, schistocytes, acanthocytes, and teardrop cells.