Main components of pomegranate, ellagic acid
and luteolin, inhibit metastasis of ovarian cancer by downregulating MMP2 and MMP9.
Abbreviation: aPTT-FS, ellagic acid
containing activated partial thromboplastin time reagent.
do not crosses the blood brain barrier it remains in blood stream with entering to other tissues and brain with topological surface area 141.34 and it is not a pgp substrate (multi-drug resistant protein).
Reanmongkol, "Topical antiinflammatory and analgesic activities of standardized pomegranate rind extract in comparison with its marker compound ellagic acid
in vivo," Journal of Ethnopharmacology, vol.
In the group of phenolic acids was revealed the presence of free ellagic acid
. The content of free ellagic acid
was not different significantly between harvesting seasons and averaged 49.1 mg/100 g FW (Table 1).
Eighteen commercially available compounds were chosen, including 11 phenolic acids (3-hydroxybenzoic acid, 3,4-dihydroxybenzoic acid, 4-hydroxybenzoic acid, caffeic acid, vanillic acid, syringic acid, p-coumaric acid, chlorogenic acid, rosmarinic acid, ferulic acid, and ellagic acid
), six flavonoids (galangin, kaempferol, chrysin, quercetin, myricetin, and pinocembrin), and an isoprenoid, ([+ or -])-abscisic acid, which is a plant hormone that has been previously recognised as a marker of heather honey .
suggested that ellagic acid
displays antiphotoaging activity, as the polyphenol protected against UVB-induced oxidative stress potentially through an Nrf2-dependent pathway.
(EA) (2,3,7,8-tetrahydroxy-benzopyrano [5,4,3-cde]benzopyran-5,10-dione) is a phenolic constituent that exists in such fruits and nuts as raspberries, strawberries, walnuts, longan seed, mango kernel (Soong and Barlow, 2004) and pomegranate (Wang et al., 2004).
Polyphenols from plant origin such as ellagic acid
, gallocatechins, chlorogenic, sitosterol, ferulic acids and catechins are thought to be potent anti-carcinogenic or anti-mutagenic regimes (Reddy et al., 2007; Zahin et al., 2014).
They are high in ellagitannins (ellagic acid
), which have been studied for their positive effect on various tumor types including breast, pancreas, skin, colon and prostate.
Gallic acid and ellagic acid
were purchased from Natural Remedies Pvt.
(EA) is a commonly found dietary polyphenol with antioxidant  and antiproliferative properties [23-25].