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A gene on chromosome 3q21-q23 that encodes a member of the ephrin-B receptor subfamily of receptor tyrosine kinases, which “promiscuously” bind membrane-bound ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signalling into neighbouring cells. EPHB1 regulates retinal axon guidance, ipsilaterally redirecting ventrotemporal retinal ganglion cells axons at the optic chiasm midline during nervous system development, a process that is thought to require repulsive interaction with EFNB2. In the adult nervous system, EPHB1 and EFNB3 regulate chemotaxis, proliferation and polarity of the hippocampus neural progenitors.

In addition to its role in axon guidance, EPHB1 also plays a key redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. It may also regulate angiogenesis and play a role in targeted cell migration by activating the MAPK/ERK cascade, and in adhesion by activating the JNK signalling cascade. EPHB1’s cognate/functional ephrin ligands include EFNB1, EFNB2 and EFNB3.


Ears–nose and throat, lungs, kidneys An acronym for the organs involved in Wegener's granulomatosis–WG; limited WG spares the kidneys and lacks signs of systemic vasculitis; generalized WG involves the kidneys and/or has signs of systemic vasculitis; disease exacerbation is best monitored by measuring titers of antineutrophil cytoplasmic antibodies by indirect immunofluorescence. See Wegener's granulomatosis.


a large deer; there are two species, the European elk (Alces alces) and the American moose (A. americana). The largest deer, 6 ft high at the withers and 2000 lb in weight, with a prominent Roman nose, an overhanging upper lip and a beard hanging from the lower jaw, brown body hair and white on the legs. The bulls have palmate antlers, the cows have no antlers.

elk lip
a blemish in a horse, a heavy, overhanging top lip.
References in periodicals archive ?
In Slovakia, there are a total of three game enclosures with elks, and from one of them, elks released themselves, so to speak.
That July, the Auburn Elks decided they wanted a new, larger home.
The Auburn Elks voted to merge with the Webster lodge about a month ago while the Webster Elks voted in March.
Idaho Elks Rehabilitation Hospital is a 71-licensed bed comprehensive rehabilitation facility located in Boise, Idaho.
These three were selected by their schools and judged by a panel of Elks members, based on their individual scholastic standing, school participation and involvement in community affairs.
Girls, ages 10-11: Latriece Harris of Palmdale, sponsored by Palmdale Elks Lodge 2027, first; and Alexis Rogers, Monroe School, sponsored by Kern River Valley Elks Lodge 2358, second.
Past Elk Hoop Shoot National finalists include NBA veteran Chris Mullin, former North Carolina State star Jennifer Howard and former Chicago White Sox third baseman Chris Snopek.
color) Members of Girl Scout Troop 116 and Lancaster Elks Lodge member Domingo Jaramillo raise the American flag.
But if the words of that slogan on the wall meant what he thought they did, the Elks had a responsibility to shoulder the load and do it.
The Elks National Foundation, the charitable arm of the Benevolent and Protective Order of the Elks, will award more than $4 million in scholarships this year to 500 high school seniors through its 2003 Most Valuable Student scholarship contest.
The Elks of Santa Clarita recently presented awards to members, community agencies, high school scholarship winners and Americanism contest winners during an awards ceremony held at the organization's lodge in Canyon Country.
LANCASTER - Six boys and girls ages 8 to 13 will advance to the next round of the Elks National ``Hoop Shoot'' basketball free-throw competition.