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A gene on chromosome 3q21-q23 that encodes a member of the ephrin-B receptor subfamily of receptor tyrosine kinases, which “promiscuously” bind membrane-bound ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signalling into neighbouring cells. EPHB1 regulates retinal axon guidance, ipsilaterally redirecting ventrotemporal retinal ganglion cells axons at the optic chiasm midline during nervous system development, a process that is thought to require repulsive interaction with EFNB2. In the adult nervous system, EPHB1 and EFNB3 regulate chemotaxis, proliferation and polarity of the hippocampus neural progenitors.

In addition to its role in axon guidance, EPHB1 also plays a key redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. It may also regulate angiogenesis and play a role in targeted cell migration by activating the MAPK/ERK cascade, and in adhesion by activating the JNK signalling cascade. EPHB1’s cognate/functional ephrin ligands include EFNB1, EFNB2 and EFNB3.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.


Ears–nose and throat, lungs, kidneys An acronym for the organs involved in Wegener's granulomatosis–WG; limited WG spares the kidneys and lacks signs of systemic vasculitis; generalized WG involves the kidneys and/or has signs of systemic vasculitis; disease exacerbation is best monitored by measuring titers of antineutrophil cytoplasmic antibodies by indirect immunofluorescence. See Wegener's granulomatosis.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
The elks then fled into wilderness," Stanislav Bystriansky, head of Zito, explains.Thanks to the monitoring collars, they had no problem monitoring the elk couple, male Merg and female Embla, despite the fact that normally, it is usually very hard for a human to find these animals in a forest.
"The Benevolent and Protective Order of Elks is a terrific organization'' said Amen, "and each day more than 1 million members find new ways of helping others and make positive changes in their communities.''
The animals were part of a year-round herd that reached up to 70 elk.
The police found that it was not possible to get the elk to leave the residential area and hunters were called in to terminate it, reported the Swedish newspaper Aftonbladet.
The Elks organization has been working with physically challenged children since 1928, and this is one of the 16 clinic locations throughout Illinois.
Eurasian elk used live in Slovakia and the project aimed to return the animals to Slovak nature.
The fledgling Auburn Emblem Club, composed of female relatives of Auburn Elks, first met at the Auburn Sportsman's Club in April 1959.
The Elks will hold the clinic at Marshall Browning Hospital, 900 N.
Matus said the merger reflects something that has been happening in recent years as membership in Elks lodges has declined nationally.
In their unique way, elk are just as apt to seek refuge from a predatory bird as they are to stand steadfast in the way of loud, murderous rifle fire.
Steltenkamp's new contribution to this literature is advertised as a "full interpretive biography of Black Elk," presenting the holy man's entire life story and religious journey "in one volume" for the first time.
This scene is repeated each fall, when elk in Rocky Mountain National Park migrate eastward from the high mountains to lower elevations and out into Estes Valley, where they will mate, survive the winter, and bear their young.