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A gene on chromosome 3q21-q23 that encodes a member of the ephrin-B receptor subfamily of receptor tyrosine kinases, which “promiscuously” bind membrane-bound ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signalling into neighbouring cells. EPHB1 regulates retinal axon guidance, ipsilaterally redirecting ventrotemporal retinal ganglion cells axons at the optic chiasm midline during nervous system development, a process that is thought to require repulsive interaction with EFNB2. In the adult nervous system, EPHB1 and EFNB3 regulate chemotaxis, proliferation and polarity of the hippocampus neural progenitors.

In addition to its role in axon guidance, EPHB1 also plays a key redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. It may also regulate angiogenesis and play a role in targeted cell migration by activating the MAPK/ERK cascade, and in adhesion by activating the JNK signalling cascade. EPHB1’s cognate/functional ephrin ligands include EFNB1, EFNB2 and EFNB3.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.


Ears–nose and throat, lungs, kidneys An acronym for the organs involved in Wegener's granulomatosis–WG; limited WG spares the kidneys and lacks signs of systemic vasculitis; generalized WG involves the kidneys and/or has signs of systemic vasculitis; disease exacerbation is best monitored by measuring titers of antineutrophil cytoplasmic antibodies by indirect immunofluorescence. See Wegener's granulomatosis.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Typically, males disperse farther than females in mammal re-introductions (Moehrenschlager and Macdonald, 2003; Hardman and Moro, 2006; Spinola et al., 2008; Devineau et al., 2010; Ryckman et al., 2010), although sex is not always an influential variable for elk (Larkin et al., 2004).
Elk River Tire & Auto is a locally owned auto repair shop that is your one-stop automotive service center for all of your vehicle needs.
His family farm in Garnett, Kansas, is currently raising 30 elk on 55 out of his 100-acre property.
As the Elks Grand Exalted Ruler/National President, Mr.
Early explorers in North America gave elk their name because they thought the animals resembled the European moose, with which they were familiar.
In their unique way, elk are just as apt to seek refuge from a predatory bird as they are to stand steadfast in the way of loud, murderous rifle fire.
A woman who saw the elk disputed the police account and said she did not see the animal limping a few hours before it was shot and killed.
Research that identifies causes of elk calf mortality will aid in determining the potential impact of predation on this cohort.
"We continue to be very proud of students from both high schools who recognize the need in our com- munity relating to our food pantry," said Elk Grove Township Supervisor Mike Sweeney.
Munck was one of 15 hunters to draw a Tennessee elk tag last year and one of 12 to fill that tag.
Over the years, I have enjoyed my share of success hunting oversized bull elk. But those successes have come on the back of a substantial learning curve, and have not come without repeated failures.