Other evidence of the presence of mitochondrial dysfunction in ASD patients is the fact that genes involved in the electron transport chain
are downregulated (decreased Complex I, III, IV, and V).
As the photosynthetic process is turned on and electrons start flowing from PSII acceptors to downstream components of the electron transport chain
the RCIIs reopen.
This leads to formation of acetate and NADH, which are then oxidized by the mitochondrial electron transport chain
There are three major reactions that occur in cellular respiration: glycolysis, the Krebs cycle, and the electron transport chain
In the present investigation, we have evaluated mitochondrial LPO, 8-oxo-dG, oxidized glutathione, reduced glutathione, ATP, lipoic acid, TCA cycle enzymes and electron transport chain
(ETC) complex activities in the brain of young versus aged rats.
As mentioned earlier, ethanol metabolism by CYP2E1 and NADH oxidation by the electron transport chain
generate ROS that results in lipid peroxidation.
In the November 2003 Journal of Neuroscience, Emory researchers Tim Greenamyre and Todd Sherer report that rotenone does its damage within the neuron's mitochondria by inhibiting a crucial enzyme in the electron transport chain
known as complex I.
State-of-the-art techniques, such as cybrid analysis of electron transport chain
defects in the differentiation of nuclear encoded or mitochondrial encoded defects, are also included in this thin book.
Cytochrome C oxidase (CO) is an electron transport chain
Using our yeast-based chemogenomic screening platform and subsequent follow-up work in human cancer cells, we were able to clearly show that elesclomol works in the cell's mitochondrion, where it interacts with the electron transport chain
to cause rapid cell death.