Defining the gap between electrographic seizure
burden, clinical expression and staff recognition of neonatal seizures.
Seizure in epilepsy may be distinguished into clinical seizure that can be apparently seen and electrographic seizure
which is only present on EEG recording findings.
The inclusion criteria were as follows: (1) the patients with refractory seizures of neonatal onset were treated with at least two antiepileptic drugs (AEDs) to control the seizure; (2) severely abnormal background and at least one electrographic seizure
detected by multichannel video-EEG (vEEG); (3) the patients were followed till at least 1 year old and survived with developmental delay.
A single dose or two doses of TFS were administered via TCRE where TFS was triggered automatically by a realtime tEEG-based electrographic seizure
activity detector .
The electrographic NCSE in the obtunded patient (also referred to as nontonic-clonic status epilepticus (SE) or subtle SE) consists of at least 30 minutes of marked obtundation or coma, without clonic activity, cyclic changes in behavioral level or level of consciousness, and continuous electrographic seizure
activity on EEG .
The former group had a lower electrographic seizure
burden (quantified as log units of continuous seizure activity in seconds) among neonates who did not have status epilepticus (6.0 vs.
Furthermore, seven had clinical and/or electrographic seizure
resolution within 7 days, and nine had such resolution within 1 month.
(13) Stimulus-induced rhythmic, periodic, or ictal discharges are associated with poor neurological outcome, (14) subclinical status epilepticus, traumatic or anoxic brain injury, (15,16) and electrographic seizures
. (16) Various and frequent nursing interventions such as airway suctioning and repositioning of the patient are necessary to avoid complications.
during therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy.
EEG criteria for the diagnosis of SE include frequent repetitive electrographic seizures
and repetitive generalized or focal epileptiform discharges of greater than 3 Hz.
Carpenter et al., "Electrographic seizures
in pediatric ICU patients: Cohort study of risk factors and mortality," Neurology, vol.