Compounds 2-11 were tested on their ability to alter bacterial growth, biofilm formation, Quorum Sensing process, and elastase
activity of P.
A method to determine the influence of the distortion of the helix on the resistance against enzymatic degradation is the use of elastase
as a degrading enzyme.
Antineutrophil cytoplasmic antibodies reacting with human neutrophil elastase
as a diagnostic marker for cocaine-induced midline destructive lesions but not autoimmune vasculitis.
The first attributed locus was the elastase
Fecal pancreas elastase
1 was measured in nonprocessed stool samples with a commercially available ELISA (ScheBo[R] Biotech AG).
In normal wounds, elastase
and other proteases do a good job of breaking down dying tissue and clearing debris from the site," says Kel Cohen, director of the Division of Plastic and Reconstructive Surgery at the MCV Wound Healing Center.
Staining with antibodies against myeloperoxidase, chloroacetate-esterase, and neutrophilic elastase
revealed no loss of the respective antigens in the myeloid population.
When this virus attacks the heart, it triggers the production of an enzyme called elastase
that destroys heart cells and creates scar tissue," said Marlene Rabinovitch, MD, head of cardiovascular research at HSC.
This enzyme, called neutrophil elastase
, is what causes the emphysema, and you don't have to be a smoker to get it (usually when one is in the 30s or 40s).
Zemaira, a human-derived alpha-1 proteinase inhibitor, acts to inhibit the activity of another protein, neutrophil elastase
, which, left unchecked, can degrade the lining of the lungs and lead to pulmonary disease.
We believe CTX-4430's ability to reduce neutrophil elastase
in the airways of CF patients has the potential to preserve lung function in CF patients, irrespective of patient-specific CF gene mutation," said Greg Duncan, President and CEO of Celtaxsys.
The effects of treatment in the rats were assessed by biochemical (articular elastase
, MPO, LPO, GSH, catalase, SOD and NO), inflammatory mediators (IL-1[beta], IL-6, TNF-[alpha], IL-10, IFN-[gamma] and [PGE.