that have an impact on inflammation, docosanoids act as neuroprotective agents: "Docosanoids include neuroprotectin D1 (NPD1), maresins, neuroprostanes (NeuroPs), and related 22-C derivatives.
Inflammation is partially regulated through the eicosanoid
The increased consumption of LNA results in an increase in EPA and DHA phospholipids in the membrane of immune cells, enhancing the synthesis of eicosanoids
with anti-inflammatory properties such as in PGE3 and LTB5, which consequently decreases the synthesis of AA (Prini et al., 2010; Calder, 2007).
have anti-inflammatory and immunoregulatory effects .
Considering that CTX induces [PGE.sub.2] and [LXA.sub.4] by macrophages at different experimental conditions , we also evaluated these eicosanoids
in supernatants of DCs.
(115) Hydrolysis of microparticular phospholipids by s[PLA.sub.2]-IIA results in production of pro-inflammatory eicosanoids
and lysophospholipids as well as in release of mitochondrial DNA as a danger-associated molecular pattern (DAMP).
sativa inhibits eicosanoid
generation in leukocytes and lipid peroxidation.
Jackson Roberts II, "Noncyclooxygenase oxidative formation of a series of novel prostaglandins: analytical ramifications for measurement of eicosanoids
," Analytical Biochemistry, vol.
Similarly, PPAR[alpha] is activated by a wide range of different fatty acids and eicosanoids
Mechanical stimulations result in a release of cell mediators, such as histamine, eicosanoids
, and cytokines, that causes the associated symptoms.
Various markers of airway inflammation and oxidative stress such as cytokines, eicosanoids
, nitric oxide, urates, and hydrogen peroxide have been shown to be increased in EBC of patients with asthma.[sup],,,, The method of collecting EBC is easy, and the cost is low.
(11,12,13) Short chain EFA-Omega (6) (Linoleic Acid) and Omega 3 (Alpha linolenic acid) with the help of enzymes desaturase and elongase are converted to Long Chain Fatty Acids, AAArachidonic Acid, GLA-Gamma linolenic acid, DGLA-DihomoGLA, EPA-Eicosapentaenoic Acid, DHA- Docosahexaenoic Acid which are further converted to eicosanoids
(PGProstaglandins, PGI-Prostacyclins, TX-Thromboxane by the enzyme Cyclooxygenase and LT-Leukotrienes by the enzyme15-Lypoxygenase).