eicosanoid


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eicosanoid

(ī′kō-sə-noid′)
n.
Any of a group of substances that are derived from arachidonic acid, including leukotrienes, prostaglandins, and thromboxanes.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

eicosanoid

A 20-carbon cyclic fatty acid derived from arachidonic acid that is synthesised from membrane phospholipids. Eicosanoids and other arachidonic acid metabolites (e.g., HETE, HPETE, leukotrienes, prostaglandins and thromboxanes) are site-specific, increase during shock and after injury, and have diverse functions, including bronchoconstriction, bronchodilation, vasodilation and vasoconstriction.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

eicosanoid

Physiology A 20-carbon cyclic fatty acid which with its arachidonic acid metabolites–eg, HETE, HPETE, leukotrienes, PGs, and thromboxanes, are site-specific, ↑ during shock and after injury, have diverse functions–eg, bronchoconstriction, bronchodilation, vasodilation, vasoconstriction. See Arachidonic acid, Bad eicosanoid, Good eicosanoid, Zone-favorable diet.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

eicosanoid

(ī-kō′să-noyd″)
Any of several autocrine or paracrine cytokines formed from the metabolism of arachidonic acid. They include prostaglandins, thromboxanes, and leukotrienes.
Medical Dictionary, © 2009 Farlex and Partners
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References in periodicals archive ?
The eicosanoid pathway is a signaling pattern that regulates inflammation when needed.
Fish Oil Reduces the Fires of Inflammation
These eicosanoids have anti-inflammatory and immunoregulatory effects [85].
Wound Healing and Omega-6 Fatty Acids: From Inflammation to Repair
After activating the column, the samples were passed and the eicosanoids were eluted from the column with 1 mL of water, 1 mL of ether, and 2 mL of methyl formate.
Crotoxin Isolated from Crotalus durissus terrificus Venom Modulates the Functional Activity of Dendritic Cells via Formyl Peptide Receptors
In terms of signal transduction, the phospholipase [A.sub.2] ([PLA.sub.2]) reaction, which hydrolyzes the sn-2 position of phospholipids to yield fatty acids and lysophospholipids, has been considered to be of particular importance, since arachidonic acid (AA, C20:4), one of the polyunsaturated fatty acids (PUFAs) released from membrane phospholipids by [PLA.sub.2], is metabolized by cyclooxygenases (COXs) and lipoxygenases (LOXs) to lipid mediators including prostaglandins (PGs) and leukotrienes (LTs), which are often referred to as eicosanoids (Fig.
Lipoquality control by phospholipase [A.sub.2] enzymes
Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation.
Evaluation of anti-inflammatory activity of Nigella sativa: an experimental study
Levine, "Altered eicosanoid levels in human colon cancer," The Journal of Laboratory and Clinical Medicine, vol.
Alleviating Promotion of Inflammation and Cancer Induced by Nonsteroidal Anti-Inflammatory Drugs
Hence, there is a growing interest in pharmacological modulation of eicosanoid production in attempt to control the evolution of T.
Cardioprotective actions of curcumin on the pathogenic NFAT/COX-2/prostaglandin [E.sub.2] pathway induced during Trypanosoma cruzi infection
Competitive inhibition-EPA and DGLA compete for COX and LOX, thereby reducing the output of AA eicosanoids.
Twelve weeks treatment outcome of omega-3 fatty acid in computer vision syndrome dry eye: an open label, randomized, controlled pilot study
Aside from TLR signalling, C4 possibly exerts its antiinflammatory effects through modulation of the eicosanoid pathway.
Diabetes mellitus and increased tuberculosis susceptibility: the role of short-chain fatty acids
For quantitative catecholamine and eicosanoid determination, the limit of detection or quantification was determined from the daily calibration curve, and absolute quantification was performed with stable isotope-labeled standards.
Quality markers addressing preanalytical variations of blood and plasma processing identified by broad and targeted metabolite profiling
Therefore, supplementation with MPL is expected to be more effective in a relatively lower dose than fish oil or ethyl ester formulations regarding eicosanoid synthesis and its implications.
Effects of marine phospholipids extract on the lipid levels of metastatic and nonmetastatic prostate cancer patients
As a rule, diet fatty acids may affect the immune response by conditioning 1) plasmatic membrane fatty acid composition and its subsequent effects on the membrane's physical qualities (TOCHER, 1995), 2) cytokines and eicosanoid production, synthesized from the precursors eicosapentaenoic (20:5 n-3, EPA) and arachidonic (20:4 n-6, ARA) acids, which are the key cell messengers in the inflammation process (ROWLEY et al., 1995), and 3) transcription regulation of genes responsible for immune responses (MONTERO et al., 2008).
Dietary lipid sources affect freshwater catfish jundia, Rhamdia quelen, survival, when challenged with Aeromonas hydrophila/Fontes lipidicas da dieta afetam a sobrevivencia do bagre de agua doce jundia, Rhamdia quelen, quando desafiados com Aeromonas hydrophila

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