eicosanoid

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eicosanoid

(ī′kō-sə-noid′)

Any of a group of substances that are derived from arachidonic acid, including leukotrienes, prostaglandins, and thromboxanes.

eicosanoid

A 20-carbon cyclic fatty acid derived from arachidonic acid that is synthesised from membrane phospholipids. Eicosanoids and other arachidonic acid metabolites (e.g., HETE, HPETE, leukotrienes, prostaglandins and thromboxanes) are site-specific, increase during shock and after injury, and have diverse functions, including bronchoconstriction, bronchodilation, vasodilation and vasoconstriction.

eicosanoid

Physiology A 20-carbon cyclic fatty acid which with its arachidonic acid metabolites–eg, HETE, HPETE, leukotrienes, PGs, and thromboxanes, are site-specific, ↑ during shock and after injury, have diverse functions–eg, bronchoconstriction, bronchodilation, vasodilation, vasoconstriction. See Arachidonic acid, Bad eicosanoid, Good eicosanoid, Zone-favorable diet.

eicosanoid

(ī-kō′să-noyd″)

Any of several autocrine or paracrine cytokines formed from the metabolism of arachidonic acid. They include prostaglandins, thromboxanes, and leukotrienes.

References in periodicals archive ?

2], is metabolized by cyclooxygenases (COXs) and lipoxygenases (LOXs) to lipid mediators including prostaglandins (PGs) and leukotrienes (LTs), which are often referred to as eicosanoids (Fig.

Lipoquality control by phospholipase [A.sub.2] enzymes

Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation.

Evaluation of anti-inflammatory activity of Nigella sativa: an experimental study

Hence, there is a growing interest in pharmacological modulation of eicosanoid production in attempt to control the evolution of T.

Cardioprotective actions of curcumin on the pathogenic NFAT/COX-2/prostaglandin [E.sub.2] pathway induced during Trypanosoma cruzi infection

Competitive inhibition-EPA and DGLA compete for COX and LOX, thereby reducing the output of AA eicosanoids.

Twelve weeks treatment outcome of omega-3 fatty acid in computer vision syndrome dry eye: an open label, randomized, controlled pilot study

5, 2, 5, and 16 h, aliquots were taken out of the samples to allow for each 10-12 replicates of MxP Broad Profiling, MxP Catecholamines, and MxP Eicosanoids as described below.

Quality markers addressing preanalytical variations of blood and plasma processing identified by broad and targeted metabolite profiling

Another significant difference between both groups of subjects was found in the initial values of ALA, possibly due to a higher eicosanoid biosynthesis from n-6 FA.

Effects of marine phospholipids extract on the lipid levels of metastatic and nonmetastatic prostate cancer patients

Although these fish had ARA in their membranes for eicosanoid synthesis, they also contained DHA to generate resolvins for an inflammation process better resolution.

Dietary lipid sources affect freshwater catfish jundia, Rhamdia quelen, survival, when challenged with Aeromonas hydrophila/Fontes lipidicas da dieta afetam a sobrevivencia do bagre de agua doce jundia, Rhamdia quelen, quando desafiados com Aeromonas hydrophila

A second level of regulation, which determines the specific eicosanoid produced following PGH2 production, is via the expression of intermediate and terminal enzymes, which include cPGES and mPGES, prostacyclin synthase, and brain or hematopoietic isoforms of prostaglandin D synthase (bPGDS, hPGDS).

Activation of diverse eicosanoid pathways in osteoarthritic cartilage a lipidomic and genomic analysis

Ongoing investigations of eicosanoid metabolites in the laboratory have led to the discovery of novel therapeutic targets for cardiovascular diseases.

2 HEC Scholars Complete Post-Doctorate from USA

In fact, increased production of free radicals during muscle activity is results of oxidative phosphorylation in mitochondrial, synthesis of eicosanoid and by some enzymatic reactions (primarily xanthin oxidase) and these processes lead to oxidative modification of proteins, including the antioxidant enzymes, and at the same time reducing their protective care which results in pro-antioxidants imbalance.

Activity of superoxide dismutase during acute exercise in athletes

Prostacyclin opposes the effects of thromboxane, a thrombogenic and atherogenic eicosanoid.

Clinical pharmacology: non-steroidal anti-inflammatory drug use in sports medicine

Lipoxins contain a trihydroxytetraene group and are members of the eicosanoid family that are produced within the vascular lumen, primarily via platelet- leukocyte transcellular biosynthesis.