efflux pump


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efflux pump

A cell membrane protein channel that selectively admits or excludes chemicals from the cytoplasm. In some bacteria efflux pumps prevent their cells from accumulating antibiotics, contributing to drug resistance.
See also: pump
References in periodicals archive ?
Use of an Efflux Pump Inhibitor To Determine the Prevalence of Efflux Pump-Mediated Fluoroquinolone Resistance and Multidrug Resistance in Pseudomonas aeruginosa.
Carnosic acid is an efflux pumps modulator by dissipation of the membrane potential in Enterococcus faecalis and Staphylococcus aureus.
The most important mechanism of fluoroquinolone resistance is the overexpression of efflux pumps with DNA gyrase and topoisomerase IV mutations.
2001) Characterization of P55, a multidrug efflux pump in Mycobacterium bovis and Mycobacterium tuberculosis.
To assess the potential activity of the 13 compounds as efflux pump inhibitors, a real-time EtBr accumulation assay in a S.
This organism has multiple mechanisms for resistance including an impermeable outer membrane, enzymes which breakdown of antibiotics especially AmpC AY-lactamases, class D OXA-type and class B metallo-AY-lactamases which allow the organism to resist carbapenems, porin channels alterations as well as efflux pumps, and other genetic changes that may lead to resistance to fluoroqui-nolones.
The gram-negative cells have two membranes, with space in between that not only makes them more difficult to treat but also requires a remedy that will scavenge the endotoxins shed from the outer cell wall and a synergist that will act against the efflux pump in the cell.
Role of efflux pumps and topoisomerase mutations in fluoroquinolone resistance in Campylobacter jejuni and Campylobacter coli.
Clinical impact of the over-expression of efflux pump in nonfermentative gram-negative bacilli, development of efflux pump inhibitors.
The mtrR gene encodes a repressor of a bacterial efflux pump that exports antibiotics, including macrolides, out of the bacteria.
Effect of efflux inhibitors on minimum inhibitory concentration (MIC) levels of OFL : To determine the extent of the efflux pump mediated ofloxacin resistance in M.