1-([.sup.1]H-Indol-3-yl)ethanamine derivatives as potent Staphylococcus aureus NorA efflux pump
Antimicrobial Activities of New Indole Derivatives Containing 1,2,4-Triazole, 1,3,4-Thiadiazole and Carbothioamide/1,2,4-Triazol, 1,3,4-Tiyadiazol ve Karbotiyoamit Iceren Yeni Indol Turevlerinin Antimikrobiyal Aktiviteleri
In this study, the MexAB-OprM efflux pump
was overexpressed only 3 of 15 meropenem resistant isolates.
To confirm the presence of active efflux pump
system, carbonyl cyanide m-chlorophenylhydrazone (CCCP) (from Sigma Aldrich) as an efflux pump
inhibitor was added to each of M-H agar plates including 0.5 to 128 [micro]g/mL ciprofloxacin.
The multidrug resistance (MDR) observed in Gram-positive bacteria is mostly attributed to overexpression of efflux pumps
and antibiotics-degrading enzymes.
Amaral, "Mechanisms of drug efflux and strategies to combat them: challenging the efflux pump
of Gram-negative bacteria," Biochimica et Biophysica Acta, vol.
Guan et al., "Effects of efflux pump
inhibitors on colistin resistance in multidrug-resistant gram-negative bacteria," Antimicrobial Agents and Chemotherapy, vol.
aureus strain RN 7044 carrying the plasmid pWBG32 which encodes the NorA efflux pump
(Pillai, Pillai, Shankel, & Mitscher, 2001).
Evaluation of efflux pumps
gene expression in resistant Pseudomonas aeruginosa isolates in an Iranian referral hospital.
aureus efflux pump
. Further studies are required to assess their composition and potential clinical relevance.
Walmsley, "Structure and function of efflux pumps
that confer resistance to drugs," Biochemical Journal, vol.
Firstly we have synthesized some antibacterial compounds, that is, 2 and 3, out of which compounds 2 and 3 reacted with gallic acid and indole acetic acid, well-known efflux pump
inhibitors, to get dual-action hybrids 4 and 5.
Zhang, "Role of the CmeABC efflux pump
in the emergence of fluoroquinolone-resistant Campylobacter under selection pressure," Journal of Antimicrobial Chemotherapy, vol.