efflux pump


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efflux pump

A cell membrane protein channel that selectively admits or excludes chemicals from the cytoplasm. In some bacteria efflux pumps prevent their cells from accumulating antibiotics, contributing to drug resistance.
See also: pump
References in periodicals archive ?
To confirm the presence of active efflux pump system, carbonyl cyanide m-chlorophenylhydrazone (CCCP) (from Sigma Aldrich) as an efflux pump inhibitor was added to each of M-H agar plates including 0.5 to 128 [micro]g/mL ciprofloxacin.
The multidrug resistance (MDR) observed in Gram-positive bacteria is mostly attributed to overexpression of efflux pumps and antibiotics-degrading enzymes.
Amaral, "Mechanisms of drug efflux and strategies to combat them: challenging the efflux pump of Gram-negative bacteria," Biochimica et Biophysica Acta, vol.
Guan et al., "Effects of efflux pump inhibitors on colistin resistance in multidrug-resistant gram-negative bacteria," Antimicrobial Agents and Chemotherapy, vol.
Evaluation of efflux pumps gene expression in resistant Pseudomonas aeruginosa isolates in an Iranian referral hospital.
aureus efflux pump. Further studies are required to assess their composition and potential clinical relevance.
Walmsley, "Structure and function of efflux pumps that confer resistance to drugs," Biochemical Journal, vol.
Firstly we have synthesized some antibacterial compounds, that is, 2 and 3, out of which compounds 2 and 3 reacted with gallic acid and indole acetic acid, well-known efflux pump inhibitors, to get dual-action hybrids 4 and 5.
Zhang, "Role of the CmeABC efflux pump in the emergence of fluoroquinolone-resistant Campylobacter under selection pressure," Journal of Antimicrobial Chemotherapy, vol.