Cyclamate, derived from N-cyclo-hexyl-sulfamic acid (CHS), and amply utilized as a non-caloric artificial edulcorant in foods and beverages as well as in the pharmaceutical industry.
Beginning in 1959, the Food and Drug Administration (FDA) added cyclamate to the list of sale substances, thus permitting its use as a non-caloric artificial edulcorant for diabetics.
Although many others authors have detected hepatic alterations induced by sodium cyclamate, (Boop et al.), some others studies did not verify evidence of hepatic toxicity, even in biopsies from the livers of rats, mice, dogs and monkeys (Richards et al., 1951 ; Taylor et al., 1968; Branton et al., 1973; Coulston et al., 1975), which could be related to edulcorant use.
However, many of these presented inflammatory lesions and vacuolizations that, according to the author, are associated uniquely with the osmotic effect of edulcorant.