edrophonium test

edrophonium test

The use of edrophonium chloride to test for the presence of myasthenia gravis. The appropriate dose is injected intravenously; if there is no effect, a larger dose is given within 45 sec. A positive test demonstrates brief improvement in strength unaccompanied by lingual fasciculation. The test may also be used to determine an overdose of a cholinergic drug. An excessive dose of cholinergic drug produces weakness that closely resembles myasthenia. A very small dose of edrophonium chloride given intravenously worsens the weakness if it is due to cholinergic drug overdose and improves it if it is due to myasthenia gravis.

CAUTION!

The test should not be performed unless facilities and staff for respiratory resuscitation are immediately available.
References in periodicals archive ?
Improvement in ptosis was not observed with the edrophonium test, upward gaze test, and ice test.
Ordinarily, the repetitive nerve stimulation test, the edrophonium test, anti-acetylcholine receptor antibody (anti-AChR-Ab) titers, and the ice test are used for MG diagnosis [5].
Electromyography testing, edrophonium test, and antibody tests are used in conjunction with the clinical and neurological history and exam to support a diagnosis of MG.
Investigations performed at this time had confirmed normal electrolytes, normal renal function, normal creatine kinase levels, normal cardiac enzymes, a normal short synacthen test, normal thyroid function and a normal edrophonium test. An initial neurological examination demonstrated brisk reflexes, one down-going and one equivocal plantar reflex and small muscle wasting in the right hand.