Administration of the acetylcholinesterase inhibitor edrophonium
resulted in strong and immediate improvement of ptosis, bulbar symptoms, and limb weakness.
We did not perform IV or IM edrophonium
tests on our patient due to the possible side effects and lack of edrophonium
in our country.
Clinical concentrations of edrophonium
enhance desensitization of the nicotinic acetylcholine receptor.
Hayes et al., "Positive Response to Edrophonium
in Patients with Neurotoxic Envenoming by Cobras (Naja naja philippinensis)," The New England Journal of Medicine, vol.
In cases where snake envenomation and tick are less likely (or have been ruled out) and the index of suspicion for MG is high, the clinical response to a test dose of edrophonium
or pyridostigmine may be a good diagnostic option.
Improvement in ptosis was not observed with the edrophonium
test, upward gaze test, and ice test.
Tensilon test by injection of IV edrophonium
and demonstration of improvement of muscle weakness is usually reserved in patients with typical clinical features and negative serological and electrophysiological testing .
Sepsis attenuates the intensity of the neuromuscular blocking effect of d-tubocurarine and the antagonistic actions of neostigmine and edrophonium
accompanying depression of muscle contractility of the diaphragm.
This test is carried out by intravenous (IV) injection of edrophonium
(Tensilon) and then by following the development of muscle weakness in the next 30-90 seconds.
ANTICHOLINESTERASE DRUGS: Renal excretion accounts for approximately 50% of the clearance of neostigmine and approximately 75% of elimination of edrophonium
Ordinarily, the repetitive nerve stimulation test, the edrophonium
test, anti-acetylcholine receptor antibody (anti-AChR-Ab) titers, and the ice test are used for MG diagnosis .
chloride test was interpreted as positive for myasthenia gravis, and intravenous immune globulin treatment was initiated.