edrophonium


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edrophonium

 [ed″ro-fo´ne-um]
a cholinergic used in the form of the chloride salt as a curare antagonist and diagnostic agent in myasthenia gravis.

edrophonium

A drug that inactivates the enzyme CHOLINESTERASE that breaks down ACETYLCHOLINE. It is used as a test for MYASTHENIA GRAVIS, a disease in which the action of acetyl choline is impaired. The brand name is Tensilon.
References in periodicals archive ?
Administration of the acetylcholinesterase inhibitor edrophonium resulted in strong and immediate improvement of ptosis, bulbar symptoms, and limb weakness.
We did not perform IV or IM edrophonium tests on our patient due to the possible side effects and lack of edrophonium in our country.
Clinical concentrations of edrophonium enhance desensitization of the nicotinic acetylcholine receptor.
Hayes et al., "Positive Response to Edrophonium in Patients with Neurotoxic Envenoming by Cobras (Naja naja philippinensis)," The New England Journal of Medicine, vol.
In cases where snake envenomation and tick are less likely (or have been ruled out) and the index of suspicion for MG is high, the clinical response to a test dose of edrophonium or pyridostigmine may be a good diagnostic option.
Improvement in ptosis was not observed with the edrophonium test, upward gaze test, and ice test.
Tensilon test by injection of IV edrophonium and demonstration of improvement of muscle weakness is usually reserved in patients with typical clinical features and negative serological and electrophysiological testing [2].
Sepsis attenuates the intensity of the neuromuscular blocking effect of d-tubocurarine and the antagonistic actions of neostigmine and edrophonium accompanying depression of muscle contractility of the diaphragm.
This test is carried out by intravenous (IV) injection of edrophonium (Tensilon) and then by following the development of muscle weakness in the next 30-90 seconds.
ANTICHOLINESTERASE DRUGS: Renal excretion accounts for approximately 50% of the clearance of neostigmine and approximately 75% of elimination of edrophonium and pyridostigmine.
Ordinarily, the repetitive nerve stimulation test, the edrophonium test, anti-acetylcholine receptor antibody (anti-AChR-Ab) titers, and the ice test are used for MG diagnosis [5].
An edrophonium chloride test was interpreted as positive for myasthenia gravis, and intravenous immune globulin treatment was initiated.