Pretreatment with 100 and 300 mg/kg doses of EE significantly reduced the edematogenic
response at 60 and 120 min compared to the control group (p<0.001).
BFRE treatment decreased the edematogenic
peak effects at 240 min but did not inhibit the total edema reported as the AUC.
A rapid procedure for the isolation of the Lys-49 myotoxin II from Bothrops moojeni (caissaca) venom: biochemical characterization, crystallization, myotoxic and edematogenic
Results of the present study show that the extract prevented the edematogenic
effects produced by histamine, which reinforces the assumption of the action on the [H.sub.1] receptor.
Homsi-Brandeburgo et al., "A rapid procedure for the isolation of the LYS-49 myotoxin II from bothrops moojeni (caissaca) venom: biochemical characterization, crystallization, myotoxic and edematogenic
activity," Toxicon, vol.
The paw thickness was measured immediately prior to carrageenan injection and at 1, 2, 4 and 6h after the administration of the edematogenic
agent using a spiral micrometer (Shengke Instrument Co., Ltd., China).
activity was inhibited in those animals that received an injection U.
A2, Area under the curves shown in A1 for the 1st, 2nd, and 3rd phase of carrageenan edematogenic
effect of EP-Mt (1 mg [kg.sup.-1]) was inhibited mainly by L-NAME (52%) and by dexamethasone (26%) (Figure 1C).
activity of scorpion venoms from the Buthid family and role of platelet-activating factor and nitric oxide in new edema induced by Tityus venoms.