The contribution of the secreted type I IFN binding protein to virus virulence and immune evasion becomes evident in mouse models of VACV and ectromelia
virus infection, where mutant viruses show an attenuated phenotype that is dramatic in the mousepox model [13, 23].
Christensen, et al., "Expression of Mouse Interleukin-4 by a Recombinant Ectromelia
Virus Suppresses Cytolytic Lymphocyte Responses and Overcomes Genetic Resistance to Mousepox," Journal of Virology 75, no.
A smallpox diagnostic panel compiled by Inger Damon s laboratory at the CDC included 12 different variola virus isolates (VAR), 13 different strains and isolates of camelpox, cowpox (CPV), ectromelia
, herpes, monkeypox, Staphylococcus aureus, vaccinia (VV), and varicella-zoster viruses (VZV).
En cambio Rainwater  reporta dos casos de ectromelia
(ausencia de un miembro) en Crocodylus moreletti.
Dr Ron Jackson, Dr Deborah Maguire, Dr Lyn Hinds and Professor Ian Ramshaw infected laboratory mice with an ectromelia
(mouse pox) virus equipped with a gene coding for zone pellucida proteins.
virus (ECTV) is the causative agent of mousepox, a severe exanthematous disease of mice in laboratory colonies and has been reported worldwide in several outbreaks and causes high economic losses in biomedical research (6).
KEY WORDS: congenital abnormalities, ectromelia
, farmworkers, fungicides, Goldenhar Syndrome, insecticides, micrognathism, pesticides, prevention and control, toxicity.
We evaluated the specificity of the PPV real-time PCR assay by use of DNA from several viruses, including orthopoxviruses (vaccinia, cowpox, monkeypox, ectromelia
, and camelpox virus), molluscum contagiosum virus, yaba-like disease virus, human herpesviruses types 1 to 8, and adenoviruses.
Some orthopoxviruses have limited host ranges; for example ectromelia
virus (ECTV) has only been described infecting captive colonies of laboratory mice (2,3).
A panel of 15 lyophilized plasma samples to which gamma-irradiated, heat-inactivated orthopox viruses (MPV, CPV, VAC, CML, and ectromelia
virus) had been added was provided by the European Network for the Diagnosis of Imported Viral Diseases (ENIVD; Berlin, Germany).
Practical PCR testing using DNA from cowpox, monkeypox, ectromelia
, parapox-ORF, myxoma, avipox, and molluscipox viruses showed no cross-reactivity.
(15) reported symmetrical hind-limb ectromelia
and ectrodactyly after R.