ectopic fat


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ectopic fat

Fat that collects in abnormal locations in the body and adversely affects health. These locations include: the liver (steatohepatitis), muscle (marbling), and around the intraperitoneal organs (visceral fat).
See also: fat
References in periodicals archive ?
Ectopic fat accumulation in liver and skeletal muscle is one factor which may be an essential link between these conditions developing in women after menopause, a time in which there is a redistribution of fat from peripheral to central deposits.
For instance, some massively obese patients have a large accumulation of subcutaneous adipose tissue without evidence of ectopic fat.
Regarding the "unexpected" finding that extremity fat was protective against elevated ALT, the researchers postulated that the "uptake and storage of free fatty acids by femoral adipose tissue could lead to protection of other organs such as the liver from exposure to fatty acids and ectopic fat deposition.
9,10) Thus, by promoting P-oxidation in non-adipose tissues and the TG synthesis in fat cells, leptin directs fat deposition toward adipocytes and limits ectopic fat deposition.
With 16 articles covering insulin resistance across a life span, the contributors detail its epidemiology, pathophysiology, and treatment in such topics as the definitions, controversies, and clinical utility of the metabolic syndrome, its epidemiology amongst children and adolescents, maternal-fetal contributors, molecular mechanisms, techniques to assess insulin action, body composition and insulin sensitivity, ectopic fat deposition and adiponectin, mediators, cardiovascular disease, polycystic ovary syndrome, the effects of exercise, and the effectiveness of weight loss medications.
Here we review: (a) the many metabolic actions of insulin, (b) the pathogenesis of type 2 diabetes mellitus, (c) insulin resistance (in general), (d) the ectopic fat hypothesis of insulin resistance, (e) the possible role of the hormones leptin, resistin, and adiponectin, and (f) the connection between insulin resistance and islet amyloid.
More is needed to be known about ectopic fat (muscle, heart, pancreas, liver), as opposed to abdominal fat, and about the biology of fat cells, particularly the impact of cytokine secretion.
OBJECTIVE: The purpose of this article was to determine the relationships among total body fat, visceral adipose tissue (VAT), fat cell size (FCS), ectopic fat deposition in liver (intrahepatic lipid [IHL]) and muscle (intramyocellular lipid [IMCL]), and insulin sensitivity index (S(i)) in healthy overweight, glucose-tolerant subjects and the effects of calorie restriction by diet alone or in conjunction with exercise on these variables.
Since the cells depicted in Figure 1B are nonadipose cells, storage of significant amounts of TGs would constitute ectopic fat deposition.