ectopic expression


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ectopic expression

The expression of a gene in a tissue in which it is not normally expressed. This occurs only in artificial situations such as in transgenic animals.
References in periodicals archive ?
Ectopic expression of rice OsNCED3 in Arabidopsis increases ABA level and alters leaf morphology.
sup][24] The control of cellular proliferation is a major function of miR-34a and ectopic expression of miR-34a could lead to the arrest of G1/G2 in cancer cells and result in the decreasing of cell doubling times.
This study has led to the identification of a novel factor, whose ectopic expression converts mouse liver cells into pancreatic cells.
The ectopic expressions of Dab2 were observed in several human malignant cancer cell lines: Data pooled from eight studies in this meta-analysis showed that the ectopic expression of Dab2 were observed in 17 human malignant cancer cell lines, including: A549, LTE, H1299, SH-SY5Y, HT1080, et al.
Previous studies have shown that perinatal exposure to the synthetic estrogen diethylstilbestrol (DES) leads to feminization of the seminal vesicle (SV) in male mice, as evidenced by tissue hyperplasia, ectopic expression of a major estrogen-inducible uterine secretory protein lactoferrin (LF), and reduced expression of SV secretory IV protein (SVS IV).
Moreover, during the last three years, advances in cellular reprogramming have demonstrated that ectopic expression of defined transcriptional factors can cause human somatic cells to revert to a pluripotent state.
In our study, the cell lysates from all ovarian cancer tissues and cell lines but not from non-malignant ovary tissues, showed expression of 95-100 kDa sortilin 1 protein indicating an ectopic expression.
Furthermore, high level ectopic expression of these Rab proteins in Leishmania acted as a dominant-negative mutant and impaired the ability of TOR to internalize the trafficking of the adenosine permease.
Edelfosine induces an apoptotic process in Leishmania infantum that is regulated by the ectopic expression of Bcl-X-L and Hrk.
Ectopic expression of EphB4 in the breast tissue of transgenic mice shows cooperative tumor induction and metastasis with neuT antigen.
Stimulating this receptor signal cascade through ectopic expression of this novel CD40L RNA results in secretion of the downstream inflammatory cytokine IL-12 from the electroporated DCs.