ectopic calcification

ec·top·ic cal·ci·fi·ca·tion

(ek-topik kalsi-fi-kāshŭn)

Calcification that occurs at an abnormal site (e.g., pulp stones, salivary calculi).

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Criteria for Gorlin syndrome Type Criteria Our patient Major Multiple (>2) basal cell carcinomas or No one diagnosed under 20 years Medulloblastoma, typically Yes desmoplastic/nodular type Odontogenic keratocysts proven by No histology [greater than or equal] 3 palmar or No plantar pits Ectopic calcification (lamellar or Yes early falx) Family history of NBCCS Questionable Minor Skeletal malformations (sella turcica, No vertebral, hands and feet) Ocular anomaly (cataract, coloboma, No microphthalmia) Rib anomalies No Macrocephaly No Cleft lip or palate No Cardiac or ovarian fibroma No Lymphomesenteric cysts No NBCCS indicates nevoid basal cell carcinoma syndrome.

Medulloblastoma in a toddler with Gorlin syndrome

Schwarz et al., "The serum protein a2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification," The Journal of Clinical Investigation, vol.

Vascular Calcification in Chronic Kidney Disease: The Role of Inflammation

Inactivation of the insulin receptor tyrosine kinase and transforming growth factor [beta] pathways are well-known biological effects of fetuin-A, and severe ectopic calcification was found in fetuin-A-deficient mice [9, 10].

Biological and Clinical Effects of Calciprotein Particles on Chronic Kidney Disease-Mineral and Bone Disorder

TNAP is the target for this drug candidate and this study in healthy volunteers will help us understand whether DS-1211 could be further studied among patients with ectopic calcification diseases, says Michael Jackson, Ph.D., senior vice president of drug discovery and development at SBP.

Japan : Sanford Burnham Prebys and Daiichi Sankyo Announce Enrollment of First Subject in a Phase 1 Clinical Trial of DS-1211 in Healthy Volunteers

Osteopontin (SPP1, OPN) is a multifunctional protein involved in a number of biological processes; chemotaxis, bone remodeling, cell adhesion, inhibition of ectopic calcification, fetal growth and development, cancer metastasis and immune modulatory functions (Schack et al., 2009).

Short Communication - Molecular Effects of Polymorphism in the 3'UTR of Osteopontin Gene in Riverine Buffalo

Broadly speaking, two major pathophysiological pathways explain the origins of ectopic calcification, namely the unregulated induction of osteogenesis and second, the loss of mineralization inhibition factors.

Vascular Calcification: Current Genetics Underlying This Complex Phenomenon

Mechanisms of ectopic calcification: implications for diabetic vasculopathy.

Abdominal Challenging Image in an Elderly Woman

Styloid process elongation or Eagle's syndrome: is there any role for ectopic calcification? Eur J Dent 2008;2(3):224-228.

EVALUATION OF STYLOID PROCESS MORPHOLOGY AND CALCIFICATION TYPES IN BOTH GENDERS WITH DIFFERENT AGES AND DENTAL STATUS/Her Iki Cinsiyette Farkli Yas ve Dis Durumlariyla Birlikte Stiloid Cikintinin Morfolojisinin ve Kalsifikasyon Tiplerinin Degerlendirilmesi

FGF23 mutation is associated with ectopic calcification [53].

Role of Vitamin D in Uremic Vascular Calcification

It is the most common form of ectopic calcification and develops around local tissue damage without any alteration to calcium or phosphate metabolism, for example, in AV.

Calcifying Acne: An Unusual Extraoral Radiographic Finding

It selectively binds to hydroxyapatite and directly inhibits the initiation and progression of ectopic calcification. Preclinical models demonstrate that SNF472 reduces the progression of calcium deposition in blood vessels and cardiac tissue.

Laboratoris Sanifit starts first clinical trial of SNF472

Instead of many hypothesis and studies, the exact etiology of styloid process and role of ectopic calcification are unknown.