ectopic bone

Also found in: Dictionary, Thesaurus, Encyclopedia.

ec·top·ic bone

(ek-top'ik bōn)
Proliferation of bone in an abnormal place.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
Early local delivery of vancomycin suppresses ectopic bone formation in a rate model of trauma-induced heterotopic ossification.
Recent studies have demonstrated that some molecular factors, such as the BMP family, HIF1a, and scleraxis, have a key role in inducing ectopic bone formation [7,14]; however, several issues remain to be elucidated.
Desmet et al., "Mechanisms of ectopic bone formation by human osteoprogenitor cells on CaP biomaterial carriers," Biomaterials, vol.
For transfemoral amputees in particular, surgical excision of the ectopic bone may result in inadequate residual soft tissue in residual limbs near joints and risk level loss or the need for more complicated procedures such as a free flap.
Key words: heterotopic implantation, autologous bone marrow, ectopic bone, bone grafting, angiogenesis, avian, pigeon, Columba livia
Here, we show a method to isolate and culture human DPSCs and use them for in situ differentiation using inorganic scaffolds for ectopic bone regeneration without requiring additional stimuli.
Quantitative analysis of BV of HO in the hind-limb microCT scanning showed that 0.50 [micro]g of BMP-2 causes 1.12 [+ or -] 0.03 [mm.sup.3] (mean [+ or -] standard error) ectopic bone in the quadriceps muscle of mice with SCI and 0.08 [+ or -] 0.03 [mm.sup.3] ectopic bone in the quadriceps muscle of control mice.
Bone morphogenetic protein (BMP)-2, which plays an important role in ectopic bone formation, has been found in the shadow cells, suggesting that it may play a role in generating bone formation in pilomatrixomas.
Based on these findings, we speculate that BMP2 overexpression in adrenal ML cases is closely related to an aberrant canonical Wnt/[beta]-catenin signaling pathway, while BMP2 induction by the tumour cells may affect ectopic bone formation by transforming undifferentiated mesenchymal cells into osteoblast-like cells.
Niu et al., "The use of carbon nanotubes to induce osteogenic differentiation of human adipose-derived MSCs in vitro and ectopic bone formation in vivo," Biomaterials, vol.
MPCs were well tolerated with no cell-related serious adverse events and no ectopic bone formation at all.
(7) It is most commonly found in athletes in contact sports but ectopic bone formation is also a frequent complication in approximately 19% of total hip arthroplasties.