ectopic ACTH syndrome


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ec·top·ic ACTH syn·drome

the association of Cushing syndrome with a non-pituitary neoplasm, usually a lung carcinoma that produces ACTH.

ectopic ACTH syndrome

A condition associated with production of ACTH by tissues other than the pituitary–eg, by small cell lung cancer Clinical Similar to pituitary-dependent Cushing syndrome Management Bilateral adrenalectomy if site of ectopic ACTH is unknown, excision of nonmalignant ACTH-producing tumors. See Cushing syndrome.
References in periodicals archive ?
Gerl, "PET scan in occult ectopic ACTH syndrome: a useful tool?" Clinical Endocrinology, vol.
Ectopic ACTH syndrome. J Steroid Biochem Mol Biol 1995; 53: 139-51.
Routine inferior petrosal sinus sampling in the differential diagnosis of adrenocorticotropin (ACTH)-dependent Cushing's syndrome: early recognition of the occult ectopic ACTH syndrome. J Clin Endocrinol Metab 1991; 73:408-13.
This response is rarely seen in patients with ectopic ACTH syndrome and practically never in patients with cortisol-secreting adrenal tumors.
This clinical situation is frequently referred to as 'occult' ectopic ACTH syndrome. The reason behind this might be the indolent course of carcinoids and as reported in 44 per cent of patients, the neoplasm was initially occult (3).
Biochemically, ectopic ACTH syndrome is frequently associated with exceedingly high circulating concentrations of corticotropin (23), as seen in our patients.
However, incidental adenomas of the pituitary gland are present in up to 35 per cent of adults (27), thus that hypophysectomy occasionally yields a nonfunctioning pituitary adenoma in patients with ectopic ACTH syndrome, is not surprising.
In conclusion, ectopic ACTH syndrome due to slowly growing tumours like carcinoids usually presents with clinical features indistinguishable from classical Cushing's.