In sepsis, inflammation resulting from ROS production promotes morphological changes in erythrocytes, with the appearance of spherocytes, cup-shaped cells, and especially echinocytes
RBC showed severe poikilocytosis predominantly marked by echinocytes
, revealing a toxic disease process with alteration of the RBC membrane.
WBC Toxic granulations 28 Dohle bodies 5 Vacuolations 38 Smudge cells 32 Clefted lymphocytes 10 Hairy projections 2 Auer rods 2 RBC Anisocytosis 54 Poikilocytosis 31 Microcytosis 7 Macrocytosis 2 Hypochromasia 3 Polychromasia 35 Echinocytes
(burr cells) 19 Dacrocytes (teardrops) 16 Spherocytes 6 Target cells 2 Acanthocytes 1 Ovalocytes 28 Schistocytes 5 Stomatocytes 2 Howell-Jolly bodies 1 Basophilic stipplings 5 Platelet Clumped platelets 3 Platelet satellitosis 5 Large platelets 8 Giant platelets 8 Overall Cell Morphology Code Concordance, Overall Type % Concordance, % WBC Toxic granulations 78.
In the examinations of abnormal shapes of erythrocytes, only microcytes, macrocytes, echinocytes
and drepanocytes were discerned sporadically, once in several microscopic fields.
Marked changes in the shape of RBC from normal discocytes to echinocytes
, spherocytes, stomatocytes and acanthocytes were also observed in the blood of the rats treated with (131)I.
25-5 [micro]M for 1-48 hr) induced erythrocyte shape changes from discocytes to echinocytes
to spherocytes, accompanied by microvesicle (MV) generation.
The leukocytosis increased to a peak count of 18,400/ [micro]L, with 40% band forms and evidence of myelocytes, metamyelocytes, and echinocytes
on a peripheral smear.
Section II discusses the specifics of grading individual red blood cell abnormalities and defines a grading system described in words and images for anisocytosis, poikilocytosis, microcytosis, macrocytosis, hypochromia, polychromasia, blister cells, target cells, teardrop cells, schistocytes, sickle cells, spherocytes, acanthocytes, echinocytes
, elliptocytes, stomatocytes, Howell-Jolly bodies, basophilic stippling, Pappenheimer bodies, rouleaux, and agglutination.