echinocandin


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echinocandin

(ē-kī-nō-kan'din),
A class of antifungal compounds targeting the fungal cell wall. Action is by specific and noncompetitive inhibition of the (1,3)-β-d-glucan synthase enzyme complex that forms glucan polymers; a major component of the fungal cell wall in several pathogenic fungi.

echinocandin

(ē-kī″nō-kan′din) [Gr. echinos, hedgehog, sea urchin, + Cand(ida albicans) + -in]
Any of a class of antifungal drugs that block the synthesis of the fungal cell wall.
References in periodicals archive ?
Of particular note was the absence of infusion-related histamine reactions, a recognized effect of other drugs in the echinocandin class, and the lack of a significant infusion-associated rise in plasma histamine levels, even at the highest doses and concentrations of administered drug.
Cancidas currently enjoys the largest share of courses within the echinocandin class (66 percent), followed by Mycamine (22 percent) and Eraxis (13 percent)," stated Joyce Wedemeyer, product director at AMR.
to echinocandin LY303366, intraconazole and amphotericin B.
This finding has stimulated interest in combinations of voriconazole and terbinafine (26), voriconazole and echinocandin (36), or polyene and echinocandin (36).
Aminocandin is a member of the echinocandin class of anti-fungal agents, the first new class of such agents to be developed and introduced in more than 40 years.
We are currently conducting a multiple dose Phase I trial with aminocandin to test the safety and pharmacokinetics of this echinocandin compound for the therapy of serious fungal infections," said Dr.
International surveillance of bloodstream infections due to Candida species in the European SENTRY program: species distribution and antifungal susceptibility including the investigational triazole and echinocandin agents.
Caspofungin recently became the first echinocandin to win approval, for the treatment of aspergillosis, and probably soon will be approved for the treatment of candidemia, said Dr.
at Columbia University Medical Center demonstrated that rapid PNA FISH results led to an early switch to caspofungin, an echinocandin, for 81% of patients with C.
echinocandin, polyene, or both, but only 1 of those 3 patients survived.
Echinocandin analysis - historical and future outlook 231