ecgonine


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Related to ecgonine: Ecgonine benzoate

ecgonine

 [ek´go-nin]
the final basic product obtained by hydrolysis of cocaine and several related alkaloids.

ec·go·nine

(ek'gō-nēn, -nin),
A product of the hydrolysis of cocaine; a topical anesthetic; basis of many coca alkaloids.

ecgonine

/ec·go·nine/ (ek´go-nin) the final basic product obtained by hydrolysis of cocaine and several related alkaloids; e. methyl ester is the major hydrolytic metabolite of cocaine detectable in blood by laboratory testing.
References in periodicals archive ?
Sweat patch specimens were analyzed for COC, BE, EME, ecgonine ethyl ester, cocaethylene, norcocaine, norcocaethylene, m- and p-hydroxycocaine, and m- and p-hydroxybenzoylecgonine by modifying the method published by Huestis et al.
5 ng/patch for COC, BE, EME, ecgonine ethyl ester, and cocaethylene and 5.
Participant K had 2 patches positive for ecgonine ethyl ester; 1 of these patches also contained m- and p-hydroxycocaine.
3] Nonstandard abbreviations: COC, cocaine; SAMHSA, Substance Abuse and Mental Health Services Administration; BE, benzoylecgonine; NIDA, National Institute on Drug Abuse; EME, ecgonine methyl ester; BSTFA, N,O-bis(trimethyl)trifluoroacetamide; TMCS, trimethylchlorosllane; MTBSTFA, N-methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide; TBDMCS, tertbutyldimethylchlorosllane; and LOQ, limit of quantification.
3] Nonstandard abbreviations: COC, cocaine; BE, benzoylecgonine; EME, ecgonine methyl ester; SAMHSA, Substance Abuse and Mental Health Services Administration; LOQ, limit(s) of quantification; COC ELISA, Cozart Microplate EIA Cocaine Oral Fluid Kit; GC/MS, gas chromatography-mass spectrometry; CE, cocaethylene; TP, true-positive; FN, false-negative; FP, false-positive; and TN, true-negative.
5 Nitrazepam 77 8 Nordiazepam 150 100 Prazepam 28 287 Temazepam 130 23 Triazolam 33 10 Cocaine metabolite BE 100 100 Cocaine 9 1 Ecgonine 2 1 Ecgonine methyl ester <0.
The drug menu by class of substances included amphetamines, opiates (morphine-related compounds), methadone, cocaine, and cannabinoids, whereas the drug menu for identification/ quantification consisted of amphetamine, methamphetamine, morphine, codeine, 6-acetylmorphine, methadone, 1,5-dimethyl-3,3-diphenyl-2-ethylidene- pyrrolidine (EDDP), benzoylecgonine, ecgonine methyl ester, and 11-nor-9-carboxy-[[DELTA].
The largest differences in identification rates by country corresponded (in decreasing order) to 6-acetylmorphine, EDDP, benzoylecgonine, ecgonine methyl ester, and 11-nor-9-carboxy-[[DELTA].
When comparing clinical and forensic laboratories in the drug identification step, the mean cutoff values used by the forensic laboratories were lower for all substances except ecgonine methyl ester (Fig.
This approach would appear to be a less cumbersome way to increase the positive rate for COC than a recent method that analyzes for ecgonine [4].
Urine concentrations of ecgonine from specimens with low benzoylecgonine levels using a new ecgonine assay.
Solid-phase extraction and GC/MS quantitation of cocaine, ecgonine methyl ester, benzoylecgonine, and cocaethylene from meconium, whole blood, and plasma.