early latent syphilis

ear·ly la·tent syph·i·lis

infection with Treponema pallidum, the organism of syphilis, after the primary and secondary phases have subsided, during the first year after infection, before any manifestations of tertiary syphilis have appeared.
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High titers of nontreponemal antibodies suggest early syphilis, including primary, secondary, and early latent syphilis. Therefore, patient and provider education about these infectious stages of syphilis could be beneficial.
Patients with primary, secondary, or early latent syphilis are to be treated with a single intramuscular dose of 2.4 million units of benzathine penicillin G.
On the basis of the clinical history obtained and physical examination, our case was an early latent syphilis stage (latency within 24 months) where standard therapy consists of administration of 2.4 million units of penicillin per week for 3 cycles [9].
Placental transmission incidence is 70-100% for primary syphilis, 40% for early latent syphilis, and 10% for late latent syphilis (3).
Primary, secondary, and early latent syphilis are treated with an intramuscular injection of 2.4 million units of long-acting benzathine penicillin G.
The patient was given a diagnosis of early latent syphilis and prescribed a 14-day course of amoxicillin (6 g/day) and probenecid (1 g/d).
All patients who tested positive for syphilis were immediately sent to the reference center in order to be evaluated by a clinician for treatment with benzathine penicillin G 2.4 million units IM in a single dose (early latent syphilis) or benzathine penicillin G 7.2 million units total, administered as three doses of 2.4 million units IM each at one-week intervals (late latent syphilis or latent syphilis of unknown duration) based on Colombian guidelines.
Individuals exposed to syphilis within 90 days preceding the diagnosis of primary, secondary, or early latent syphilis in their sex partners were treated.
Primary syphilis was diagnosed in four cases, secondary syphilis in other four cases, and nine cases were classified as early latent syphilis.
One of the main and most important reasons for the growth of late syphilis (neurosyphilis, visceral syphilis) and early latent syphilis is development of the market of private healthcare services, where STI therapy is often inadequately implemented due to low-skilled medical staff, etc.
Some studies found that an increased treatment failure rate among the HIV-positive population was connected with early syphilis stage (primary and/or secondary and/or early latent syphilis) (26-28).

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