Cytotoxic CD8 T cell response against EBV infection is so dramatic that, in IM patients, up to 50% of CD8 T cells recognize EBV-specific CD8 T cell epitopes, most derived from immediate early or early antigens [13, 14].
A strong Cd8 T cell response to early antigens is key to clear the virus .
We could discount the high IgGs, NA, and VCAs as postviral infection with poor correlation with the patient's symptomatic presentation.But the stone in the shoe was the high early antigens
([greater than or equal to] 1:640), which didn't make sense in the chronic patient.
IgG antibodies to Epstein-Barr virus (EBV) viral capsid and early antigens
Antibody responses to recombinant Epstein-Barr virus antigens in nasopharyngeal carcinoma patients: complementary test of ZEBRA protein and early antigens
p54 and p138.
In brief, we used indirect immunofluorescence for IgG and IgM antibodies to the VCA and the combined restricted and diffuse components of early antigens (EA R + D).
Titers of antibodies to the Epstein-Barr early antigen and Epstein-Barr nuclear antigen, measured as P107, were correlated to concentrations of organochlorines to evaluate the possibility of an interaction between these factors in the pathogenesis of HCL.