Monoclonal antibody blockade of the human Eag1
potassium channel function exerts antitumor activity.
Short Hairpin RNA (shRNA) Ether a go-go 1 (Eag1
) inhibition of human osteosarcoma angiogenesis via VEGF/PI3K/AKT signaling.
Ether-a-go-go1 (Eag1), a voltage-gated [K.sup.+] (Kv) channel firstly identified in a leg shaking mutant phenotype of Drosophila caused by spontaneously repetitive action potential firing in motor neurons and increased transmitter release [1, 2], is conserved in diverse mammalian species including human.
In physiological conditions, both EAG1 and EAG2 channels are expressed in the brain and their distributions overlap in the cortex and olfactory bulb, but show some differential expression pattern in other specific locations such as thalamus .
In humans, EAG1 is encoded by the KCNH1 gene located on chromosome 1q32.1--32.3 .
The function of the EAG1 channels in nervous system remained elusive until recently.
The metal oxide is zinc oxide; the covering layer is a sacrificial metal; and the thicknesses (eAg1
, eAg2, eAg3) of the silver layers (Ag1, Ag2, Ag3) vary in a ratio of between 0.8 and 1.2 and are such that eAg1
[less than or equal to] eAg3 [less than or equal to] eAg2 and eAg1
corresponds to the thickness of the silver layer closest to the substrate and eAg3 corresponds to the thickness of the silver layer furthest from the substrate.
Zumga-Garcia et al., "Astemizole-based anticancer therapy for hepatocellular carcinoma (HCC), and Eag1
channels as potential earlystage markers of HCC," Tumor Biology, vol.