E-aminocaproic acid | definition of e-aminocaproic acid by Medical dictionary
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ε-aminocaproic acid [ep´sĭ-lon-ah-me″no-kah-pro´ik]
an amino acid that is a potent inhibitor of plasminogen and plasmin and indirectly of fibrinolysis; used for treatment (as aminocaproic acid) of acute bleeding syndromes due to fibrinolysis and for the prevention and treatment of postsurgical hemorrhage.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
References in periodicals archive
Both tranexamic acid and e-aminocaproic acid
, which are analogs of lysine, competitively block the binding of fibrinogen and fibrin to their lysine binding sites on plasminogen, thus reducing the rate of fibrinolysis.
The lysine analogues, TXA and e-aminocaproic acid
(EACA), are a synthetic class of antifibrinolytics.
(7) Therefore, antifibrinolytic agents such as E-aminocaproic acid
and tranexamic acid prevent the activation of plasminogen.