dystrophin-glycoprotein complex

dystrophin-glycoprotein complex (DGC)

a large oligomeric complex of proteins and glycoproteins of the sarcolemma that are critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. It includes dystrophin, sarcoglycans, dystroglycans, sarcospan, syntrophins, and dystrobrevin. Abnormalities of the plasma membrane of the muscle fiber that destroy this complex have been associated with several types of muscular dystrophy and with cardiomyopathy.
References in periodicals archive ?
Dystrophin connects to other glycoproteins to form the dystrophin-glycoprotein complex (DGC).
The dystrophin-glycoprotein complex in the prevention of muscle damage.
The relevance of the dystrophin-glycoprotein complex in cardiomyopathy has been demonstrated in mouse models of sarcoglycanopathies, in which mutations in the [beta], [delta], or [gamma] sarcoglycan genes produce both muscular dystrophy and dilated cardiomyopathy that reproduce the phenotype of the BIO-TO2 strain.