There was leaching of the herbicide picloram in
dystrophic Red Yellow Latosol (LVAd) and its leaching intensity decreased along the soil profile, regardless of limestone application.
Sixteen male
dystrophic mdx mice (C57BL/10ScSnDmdmdx/J) and controls wild-type (C57BL/10) acquired from Fiocruz Institute (Rio de Janeiro, RJ, Brazil) were used in this study.
Hayden suffers from
Dystrophic Epidermolysis Bullosa (EB), a genetic condition causing fragile, blistering skin
(B) The tumour consists of slender spindle cells arranged in arcs in a myxo-fibrillary background with
dystrophic calcification.
"SCC is a devastating complication for people with severe RDEB (recessive
dystrophic epidermolysis bullosa) and the treatments we can offer currently are really limited in effectiveness," says Dr Jemima Mellerio, who has led research into the new drug to treat the associated skin cancer.
"EB has been categorized as encompassing five major types (Simplex, Junctional,
Dystrophic, Kindler Syndrome, Aquisita) and 31 subtypes, therefore it is commonly referred to as a group of disorders.
The constellation of neuropathologic features (ventriculomegaly, mineralized neurons, and
dystrophic calcification with band-like subcortical distribution) differs from features seen in other common infections associated with congenital abnormalities (e.g., TORCH [toxoplasmosis, other viruses, rubella, cytomegalovirus and herpesvirus infections]) and should raise suspicion for congenital Zika virus infection, warranting further workup.
In the present study, we investigated the effect of OleogelS10 on wound healing in patients with
dystrophic EB.
Whilst many of these approaches have been successful in ameliorating the
dystrophic pathology of mdx mice, their translation to human trials and clinical practice has been unsuccessful [28].
Calcinosis cutis can be subdivided into 4 groups based on aetiology:
dystrophic, metastatic, iatrogenic, and idiopathic [3].
Among the potential factors involved in the pathogenesis of muscular dystrophy, oxidative stress [5, 6] might be responsible for the activation of degenerative processes and for the appearance and progress of pathologic changes in
dystrophic muscles [4].
There are three major subtypes; simplex, junctional and
dystrophic.
