The possible mechanism postulated are splenic pooling and oxidative stress causing premature platelet death and bone marrow dyspoiesis
. There is also immune mediated lysis of circulating platelets by generation of anti-platelet antibodies.
Zhu et al., "Chromosome t(7;11)(p15;p15) translocation in acute myeloid leukemia coexisting with multi-lineage dyspoiesis
and mutations in NRAS and WT1: a case report and literature review," Oncology Letters, vol.
Conventional cytogenetics shows 46,XX, t(3;3)(q21;q26) in an acute myeloid leukemia with marked dyspoiesis
(arrows indicating the break points).
Congenital heart disease refers to anatomical problems resulting from dyspoiesis
or dysplasia of heart and great vessels or cases in which the channels fail to close which is normal for fetus.
In our study the AML cases with dyspoiesis
did not have a significantly different MVD or PI when compared to those without dyspoiesis
Mild (23%) dyspoiesis
, no aggregates of Promyelocytes-Matas atypical cells identified.
Myeloid and monocytic dyspoiesis
as determined by flow cytometric scoring in myelodysplastic syndrome correlates with the IPSS and with outcome after hematopoietic stem cell transplantation.
(10,11,12) The differentiating features particular to acute leukaemia include "presentations after 6 months of age and variable WBC counts with striking dyspoiesis
. The circulating blasts in acute leukaemia are more phenotypically uniform; as opposed to a more heterogeneous blast population in TAM.