dysplastic nevus syndrome

dys·plas·tic ne·vus

a nevus exceeding 5 mm in diameter, with irregular, indistinct, or notched borders and mixed tan-to-black and pink-to-red color. Microscopically these are basally nested and scattered intraepidermal melanocytes with hyperchromatic nuclei larger than those of basal keratinocytes. If multiple and associated with a family history of melanoma, these nevi have a high risk of malignant change, but isolated dysplastic nevi in the absence of a family history of melanoma are less frequently premalignant.
See also: malignant mole syndrome.
See: dysplastic nevus syndrome.

dysplastic nevus syndrome

an inherited genetic syndrome that causes the individual to have a large number of nevi (moles), often 100 or more. These nevi tend to become dysplastic and predispose the individual to the development of malignant melanoma. Also called familial atypical mole-malignant melanoma syndrome (FAMMM) and B-K mole syndrome.

dys·plas·tic ne·vus syn·drome

(dis-plas'tik nē'vŭs sin'drōm)
Clinically atypical nevi having variable pigmentation and ill-defined borders, with an increased risk for development of cutaneous malignant melanoma; biopsies show melanocytic dysplasia.

Dysplastic nevus syndrome

A familial syndrome characterized by the presence of multiple atypical appearing moles, often at a young age.
Mentioned in: Malignant Melanoma
References in periodicals archive ?
Long-term surveillance, however, is crucial for agminated blue nevi, especially if the individual has dysplastic nevus syndrome.
There's a condition called dysplastic nevus syndrome, where individuals with multiple clinically atypical looking moles need careful vigilance; again I'd recommend caution with sun exposure, and definitely avoiding burning.
Dysplastic nevus syndrome is a distinct disorder that is inherited in an autosomal dominant manner.
Sporadic dysplastic nevus syndrome is a spontaneous mutation that increases the relative risk of malignancy up to 46 times that of the general population, he said.
Part of the University of Pittsburgh Cancer Center, it serves as an international referral center for patients with melanoma and Dysplastic Nevus Syndrome.
7% of children had sporadic dysplastic nevi and 9% had dysplastic nevus syndrome.
It is not clear if patients with dysplastic nevus syndrome have higher incidence of conjunctival nevi.
Cytogenetic analysis of conjunctival melanoma in a patient with dysplastic nevus syndrome revealed a clonal 1;14 translocation.