dysplastic nevus syndrome

dys·plas·tic ne·vus

a nevus exceeding 5 mm in diameter, with irregular, indistinct, or notched borders and mixed tan-to-black and pink-to-red color. Microscopically these are basally nested and scattered intraepidermal melanocytes with hyperchromatic nuclei larger than those of basal keratinocytes. If multiple and associated with a family history of melanoma, these nevi have a high risk of malignant change, but isolated dysplastic nevi in the absence of a family history of melanoma are less frequently premalignant.
See also: malignant mole syndrome.
See: dysplastic nevus syndrome.

dys·plas·tic ne·vus syn·drome

(dis-plas'tik nē'vŭs sin'drōm)
Clinically atypical nevi having variable pigmentation and ill-defined borders, with an increased risk for development of cutaneous malignant melanoma; biopsies show melanocytic dysplasia.

Dysplastic nevus syndrome

A familial syndrome characterized by the presence of multiple atypical appearing moles, often at a young age.
Mentioned in: Malignant Melanoma
References in periodicals archive ?
Dysplastic nevus syndrome: a phenotypic association of sporadic cutaneous melanoma.
The ABCDEFs of nail melanoma Letter Meaning: Subungual Meaning: Cutaneous A Age: Peak 5th-7th decades Asymmetry Race: African American, Native American, Asian B Band (nail band): Brown-black Border: Irregular/ Breadth: [greater than or equal to] 3 mm poorly defined Border: Irregular/blurred C Change: Rapid increase in size Color: Varied D Digit involved: Thumb > hallux Diameter: > 6 mm Single digit > multiple digits E Extension of pigment Evolving to involve nail folds (changing) F Family or personal history: Previous Funny looking melanoma or dysplastic nevus syndrome (ugly duckling) Note: Adapted from CA Cancer J Clin.
Dimov, "Primary gallbladder melanoma in dysplastic nevus syndrome: Report of case and literature review," The Turkish Journal of Gastroenterology, vol.
"There's a condition called dysplastic nevus syndrome, where individuals with multiple clinically atypical looking moles need careful vigilance; again I'd recommend caution with sun exposure, and definitely avoiding burning."
Dysplastic nevus syndrome is a distinct disorder that is inherited in an autosomal dominant manner.
Sporadic dysplastic nevus syndrome is a spontaneous mutation that increases the relative risk of malignancy up to 46 times that of the general population, he said.
Long-term surveillance, however, is crucial for agminated blue nevi, especially if the individual has dysplastic nevus syndrome. If the involved nevi develop any features of atypia, a biopsy should be performed to assess for the development of a melanoma.
(44) Dysplastic nevi can be sporadic or inherited in an autosomal dominant fashion (dysplastic nevus syndrome), and both are related to increased risk for developing melanoma.
It is not clear if patients with dysplastic nevus syndrome have higher incidence of conjunctival nevi.
Cytogenetic analysis of conjunctival melanoma in a patient with dysplastic nevus syndrome revealed a clonal 1;14 translocation.
Prevalence of primary acquired melanosis and nevi of the conjunctiva and uvea in the dysplastic nevus syndrome: a case-control study.