Witkop syndrome

(redirected from dysplasia of nails with hypodontia)

tooth-and-nail syn·drome

hypodontia associated with absent or very small nails at birth.
Synonym(s): witkop syndrome

tooth-and-nail syn·drome

hypodontia associated with absent or very small nails at birth.
Synonym(s): witkop syndrome
Farlex Partner Medical Dictionary © Farlex 2012

Witkop syndrome

A rare autosomal dominant ectodermal dysplasia (OMIM:189500) involving the teeth and nails. Most affected individuals have normal hair, sweat glands and ability to tolerate heat, with variable defects in permanent and primary teeth.
 
Molecular pathology
Defects of MSX1, which encodes a homeobox protein involved in epithelial-mesenchymal signalling that has roles in limb-pattern formation and craniofacial development, cause Witkop syndrome.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

Witkop syndrome

(wit'kop)
[C.J. Witkop, 20th-cent. Chilean dentist and oral surgeon]
Tooth and nail syndrome .
Medical Dictionary, © 2009 Farlex and Partners