Taking it to the max: The genetic and developmental mechanisms coordinating midfacial morphogenesis and dysmorphology
In addition to performing all recommended tests during and after pregnancy, the researchers plan to follow case and control infants with ophthalmologic and developmental exams as well as a CT scan if indicated, and a dysmorphology
exam in infected infants.
44) However, early identification of the physical stigmata of FASD is challenging because of the difficulty inherent in assessing dysmorphology
in infants and the considerable challenge in determining if the neuropsychological deficits that a child presents with are due to a prenatal alcohol exposure alone, as there are a multitude of non-alcohol related factors that have a significant impact on child development.
or genetic consultant is indicated in cases of hereditary disorders to determine recurrence risk for the family with subsequent offspring.
It is well known that patients with IBM are susceptible to developing DNA mitochondrial mutations and may demonstrate evidence of ultrastructural mitochondrial alterations (increased numbers of mitochondria and mitochondrial dysmorphology
, including paracrystalline mitochondrial inclusions).
The deleterious effect of ethanol on fetal development also is well-documented; major effects include intrauterine growth retardation, microcephaly, facial dysmorphology
, cardiac and renal abnormalities, mental retardation, and neonatal withdrawal syndrome (Baker & Shephard, 1994).
Both are types of subtle physical dysmorphology
(abnormal development of tissue form) indicative of developmental stress, and both are significantly more common among people with schizophrenia.
Recently, the degree of putative dysmorphology
in children with ADHD has been correlated with response to stimulant medication.
For those conditions where there have been few advances, as in the case of a wide range of dysmorphology
syndromes, the degree of genetic knowledge, both actual and potential, is the same and can therefore be described in terms of genetic uncertainty.
in Swedish schizophrenia patients.
and the orbital region: a practical clinical approach.
The timing of hazardous drinking occurring during fetal development dictates the locus and extent of neural and facial dysmorphology
sustained, resulting in fetal alcohol spectrum disorders (FASD).