Vacuolated and dyskeratotic
keratinocytes are also typically present within the epidermal invagination.
8] Pre-malignant lesions display features similar to actinic keratosis with prominent atypical dyskeratotic
6,7 In this method, scrapings from the floor of the vesicles are transferred to a glass slide, stained with various dyes, and then examined under the light microscope, that reveals multinucleated giant cells in herpetic infection, acantholytic cells in pemphigus, dyskeratotic
acantholytic cells and cocci in bullous impetigo, pseudohyphae in candidiasis and necrotic basal cells in toxic epidermal necrolysis.
The histopathologic hallmark of PNP is a predominant interface reaction pattern, characterized by basal cell vacuolar degeneration, dyskeratotic
and necrotic keratinocytes, and lymphocytic inflammation characterized by lymphocytic exocytosis with either as sprinkling of lymphocytes at the basement membrane zone or a band-like infiltrate in the upper dermis.
Subtle clues, such as superficial dyskeratotic
keratinocytes in contact dermatitis can be used, but in most circumstances, the diagnosis spongiotic dermatitis" is sufficient information for the clinician to manage the patient.
7) Typical features on cutaneous histology, such as eosinophilic spongiosis and dyskeratotic
keratinocytes, can support the diagnosis.
A histopathologic examination revealed a well-differentiated SCC with an inverted and warty growth pattern, keratinization with keratin pearl and dyskeratotic
Bilateral coats retinopathy associated with aplastic anaemia and mild dyskeratotic
Histopathology showed epidermal pseudo-epitheliomatous hyperplasia and dysmaturation with scattered dyskeratotic
keratinocytes (Figure 3a).
2) G III (3) inflammation G IV (1) Groups Dermatological (n) BMT+GVHD+MSC G I: Focal/diffuse vacuolization of basal-layer (1) G II: Subepidermal infiltration of lymphocytes (1) CsA+MTX G I: Focal/diffuse vacuolization of basal layer (3) MSC G I: Focal/diffuse vacuolization of basal layer (3) CsA+MTX+MSC G I: Focal/diffuse vacuolization of basal layer (2) BMT-CONTROL G I: Focal/diffuse vacuolization of basal-layer (4) G II: Spongiose+ dyskeratotic
Keratinocyte lymphocytes infiltration (3) G III: Subepidermal separation (1)
Insufficient calcium provided to maturing keratinocytes due to inadequate vascular supply (Nocek, 1997) or calcium unavailability due to hypocalcemia may lead to depressed transglutaminase activity and formation of dyskeratotic
The surface part of the squamous papilloma with prominent nuclear dysplasia and the loss of stratification and polarisation in hypercellular squamous epithelium were seen and also the papilloma showed prominent dysplastic figures and dyskeratotic