dysgerminoma


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dysgerminoma

 [dis-jer″mĭ-no´mah]
a solid, often radiosensitive, malignant ovarian neoplasm derived from undifferentiated germinal cells; the counterpart of seminoma of the testis.

dys·ger·mi·no·ma

(dis'jĕr-mi-nō'mă),
A malignant neoplasm of the ovary (counterpart of seminoma of the testis), composed of undifferentiated gonadal germinal cells and occurring more frequently in patients younger than 20 years of age. The neoplasms are grayish yellow and firm, contain foci of necrosis and hemorrhage, and tend to be encapsulated; characteristically, they spread by way of lymphatic vessels, but widespread metastases also occur.
Synonym(s): disgerminoma
[dys- + L. germen, a bud or sprout, + G. -ōma, tumor]

dys·ger·mi·no·ma

(dis'jĕr-mi-nō'mă)
A rare malignant neoplasm of the ovary composed of undifferentiated gonadal germinal cells and occurring more frequently in patients younger than 20 years of age. The neoplasms contain foci of necrosis and hemorrhage and tend to be encapsulated; characteristically, they spread by way of lymphatic vessels, but widespread metastases also occur.
[dys- + L. germen, a bud or sprout, + G. -ōma, tumor]
References in periodicals archive ?
Expression of CD117 (c-kit) receptor in dysgerminoma of the ovary: diagnostic and therapeutic implications.
Most common combination is that of Dysgerminoma & Yolk sac tumour.
Quirk and Natarajan have reported that approximately 75% of women with a dysgerminoma present with clinical stage Ia disease, a finding similar to our case.
Representative images of dysgerminoma. A, A few cohesive clusters of large polygonal tumor cells with pleomorphic nuclei containing prominent nucleoli and abundant vacuolated cytoplasm admixed with lymphocytes; also noted is the diagnostic "tiger-stripe" pattern in the background.
Dysgerminoma was the most common malignant germ cell tumour followed by mixed germ cell tumours.
The Differential Diagnosis of Dysgerminoma.--CD117, PLAP, OCT4, NANOG, D2-40, hCG, and CK(AE1/AE3).
Germ cell tumours of the ovary with special study of dysgerminoma. J Obstet Gynaecol India 1972;22:366-71.
The histologic profile of dysgerminoma is stereotypic and identical to that of testicular seminoma and midline germinomas.
In present study; out of all benign masses 53% were simple follicular cyst and out of all malignant masses 65% were serous cystadenocarcinoma and 35% were dysgerminoma. It was similarly reported by Farooq et al.
Specific diagnoses and clear descriptions or illustrations do reveal the existence of rare cases of nonteratomatous GCTs, including dysgerminoma, yolk sac tumor, and embryonal carcinoma.
Apart from lymphatic endothelial cells, expression of podoplanin in tumor cells has been reported in some cancer types including squamous cell carcinoma in the lung, (7-10) malignant mesothelioma, (11,12) Kaposi sarcoma, angiosarcoma, (13) hemangioblastoma, (14) dysgerminoma, (7) and brain tumors.