has also been observed in a young patient with hereditary SA by Kyung et al from Korea15.
Tumour necrosis factor may contribute to the anemia of malaria by causing dyserythropoiesis
In evaluated patients with hemoglobin levels near normal ranges, correction of biologic markers of dyserythropoiesis
Bone marrow biopsy was performed for pancytopenia and showed hypercellular bone marrow (80%) with erythroid hyperplasia and dyserythropoiesis
. Flow cytometry showed polyclonal B-cells and plasma cells; no evidence of lymphoma was found.
[beta]-TM is characterized by the absence or severe reduction of [beta]-globin chain production leading to globin chain imbalance, dyserythropoiesis
, and severe anemia.
Malarial infections, particularly those associated with Plasmodium vivax, can cause both hemolysis (the destruction of red blood cells) and dyserythropoiesis
(inadequate production of red blood cells) (Anstey et al.
Bone marrow evaluation showed marked dyserythropoiesis
. Case BIII.1 had mild microcytic anaemia, reticulocytosis, and increased ferritin levels; 17% of stomatocytes were detected at blood smear examination (Table 1 and Figure 2); the molecular testing for HBB gene revealed the presence of the splicing mutation c.93-21G>A at heterozygote level, confirming the beta-thalassemia trait.
The most seriously affected were patients from Yugoslavia, showing hemolytic anemia, dyserythropoiesis
, hepatosplenomegaly, and skeletal malformations [5, 7,11].
(6,11) Myelodysplastic syndromes with inv(3)/t(3;3) typically present with decreased platelet counts with dysmegakaryopoiesis, dyserythropoiesis
, and dysgranulopoiesis in 100%, 79.5%, and 71.8% of cases, respectively (Figure 1, A).
Red cell inclusions result from oxidant stress, severe infections and dyserythropoiesis
(14) might be less pronounced in African patients than in European patients.
showed that bone marrows which were stained within 24 hours did not show marked discernible dyserythropoiesis