Malarial infections, particularly those associated with Plasmodium vivax, can cause both hemolysis (the destruction of red blood cells) and
dyserythropoiesis (inadequate production of red blood cells) (Anstey et al.
6,11) Myelodysplastic syndromes with inv(3)/t(3;3) typically present with decreased platelet counts with dysmegakaryopoiesis,
dyserythropoiesis, and dysgranulopoiesis in 100%, 79.
Red cell inclusions result from oxidant stress, severe infections and
dyserythropoiesis (maturation defects).
Malaria-related
dyserythropoiesis (14) might be less pronounced in African patients than in European patients.
showed that bone marrows which were stained within 24 hours did not show marked discernible
dyserythropoiesis.
Like malaria, schistosomiasis can also cause anaemia as a result of destruction of red blood cells and
dyserythropoiesis.
Such reticulocyte count response for the degree of anemia in the face of erythroid hyperplasia in the marrow warrants a diagnosis of
dyserythropoiesis.
Tumour necrosis factor may contribute to the anemia of malaria by causing
dyserythropoiesis and erythrophagocytosis.
Although FGR fetuses initially increase their red blood cell mass to improve oxygenation, they often become progressively anaemic as a result of nutritional problems, insufficient bone marrow response, microvascular consumption or
dyserythropoiesis.
sup][3] BM
dyserythropoiesis and BM clone chromosomal abnormalities involving chromosomes 5, 7, and 8 have been seen in patients with MDS or AA.
The causes of anaemia in malaria include increased destruction of infected as well as uninfected RBCs by reticuloendothelial system,
dyserythropoiesis in bone marrow, depressed reticulocytes response in acute malaria, hypersplenism and folate deficiency.
Acquired aplastic anemia other acquired bone marrow failure disorder and
dyserythropoiesis.
