Confirming previous studies, we could show that these 3 sequence variations are in close linkage dysequilibrium
Vestibular evoked potentials in patients suffering from central dysequilibrium
. In: Claussen CF, Kirtane MV, Schneider D, eds.
Indeed, linkage dysequilibrium
between these 2 markers was recently demonstrated in a group of 133 healthy Caucasian individuals (14).
She had no history of hearing loss or dysequilibrium
In addition, there is possible linkage dysequilibrium
with other variants, for example, UCP3, that reside on the same chromosome as UCP2.
Interestingly, we did not find a role for the eNOS 4a4b polymorphism in influencing Hcy concentrations, although it is in close linkage dysequilibrium
with the -786T>C polymorphism and may have a cis-acting effect on eNOS gene transcription (27).
Apart from the 56C>G SNP, the other SNPs are in strong linkage dysequilibrium
, producing 3 haplotypes (11111, 22122, and 11211) representing ~98% of the population in Caucasians (5, 9); therefore, 2 independent APOA5 SNPs (56C>G and -1131T>C) can be analyzed in association studies as indicators of the corresponding haplotypes.
was apparent between CYP2C8*3 and CYP2C9*2; seven of the eight (87.5%) volunteers with the CYP2C8*3 allele also had the CYP2C9*2 allele.