Not included in the data set, but suggested, is the pattern of invasion, because patients with squamous cell carcinoma with a dyscohesive
, tentacular pattern of infiltration have a higher risk of recurrence compared with those with pushing borders.
Neoplastic cells were dyscohesive
, having round-oval nuclei with finely granular to vesicular chromatin.
Sheets of dyscohesive
atypical cells with large hyperchromatic round nuclei and scant cytoplasm.
(6,7,8) It contains cells that are dyscohesive
with large hyperchromatic nuclei, high degrees of anaplasia and atypical mitotic figures.
TLC is a rare and unique variant of invasive breast carcinoma as its name suggest, displays an admixture of minimally pleomorphic invasive tubules, as seen in classic tubular carcinoma and dyscohesive
cells with lower nuclear grade, as seen in classic lobular carcinoma.
The tumor cells are bizarre, oval to spindle-shaped, dyscohesive
elements showing anisocytosis, and irregular sometimes multiple nuclei, perfectly reflecting the sarcomatoid or epithelioid histological morphology.
Microscopic examination: Ultra sonographically, guided fine needle aspiration cytology of the mass revealed dyscohesive
clusters of large tumor cells with granular chromatin with prominent nucleoli and moderate eosinophilic cytoplasm admixed with lymphocytes.
However, caution should be used because dyscohesive
lymphocytes and epithelioid histiocytes should not be misdiagnosed as tumor cells.
Ultrasound-guided fine needle aspiration cytology (FNAC) of the mass was performed, which showed malignant small round blue cells arranged in nests and dyscohesive
sheets having fine chromatin, high N: C ratio, inconspicuous nucleoli and scant cytoplasm (Fig.
The smears showed malignant cells scattered singly, arranged in dyscohesive
groups and clusters with branching capillaries, cords and ill formed acini.
The Diff-Quik smear revealed a population of dyscohesive
atypical cells with large nuclei with a fine chromatin pattern and small, inconspicuous nucleoli; a high nuclear to cytoplasmic ratio; and a very thin rim of basophilic cytoplasm in a clean background.
The cytologic findings revealed cell rich smears comprising of dyscohesive
sheets of monomorphic population of small and large round cells with scant pale-blue cytoplasm.