dyscohesive

dyscohesive

adjective A term of art referring to loosened intercellular connections, especially between epithelial cells, which is one of the histologic features of early malignancy.
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The Diff-Quik smear revealed a population of dyscohesive atypical cells with large nuclei with a fine chromatin pattern and small, inconspicuous nucleoli; a high nuclear to cytoplasmic ratio; and a very thin rim of basophilic cytoplasm in a clean background.
6,7,8) It contains cells that are dyscohesive with large hyperchromatic nuclei, high degrees of anaplasia and atypical mitotic figures.
TLC is a rare and unique variant of invasive breast carcinoma as its name suggest, displays an admixture of minimally pleomorphic invasive tubules, as seen in classic tubular carcinoma and dyscohesive cells with lower nuclear grade, as seen in classic lobular carcinoma.
Microscopic examination: Ultra sonographically, guided fine needle aspiration cytology of the mass revealed dyscohesive clusters of large tumor cells with granular chromatin with prominent nucleoli and moderate eosinophilic cytoplasm admixed with lymphocytes.
Ultrasound-guided fine needle aspiration cytology (FNAC) of the mass was performed, which showed malignant small round blue cells arranged in nests and dyscohesive sheets having fine chromatin, high N: C ratio, inconspicuous nucleoli and scant cytoplasm (Fig.
Undifferentiated carcinomas consist of sheets of dyscohesive, high-grade but uniform cells with necrosis (Figure 1, A).
The smears showed malignant cells scattered singly, arranged in dyscohesive groups and clusters with branching capillaries, cords and ill formed acini.
The cytologic findings revealed cell rich smears comprising of dyscohesive sheets of monomorphic population of small and large round cells with scant pale-blue cytoplasm.
For instance, rhabdoid tumor of the kidney is composed of dyscohesive round or polygonal cells having a round or indented nucleus with a central eosinophilic nucleolus.
The tumor is composed of large, dyscohesive tumor cells with coarse chromatin, distinct nucleoli, and abundant amphophilic cytoplasm (Figure 2, b).
Lobular carcinoma in situ (LCIS) was defined as a lesion in which more than 50% of the acini of a terminal duct--lobular unit were dilated and completely filled by uniform, small, and dyscohesive cells with bland nuclei, uniform chromatin, and indistinct nucleoli, whereas ductal carcinoma in situ (DCIS) was characterized by a single cell population showing cytologic pleomorphism, presence of mitoses, or singlecell necrosis and an appropriate growth pattern in at least 2 duct spaces.
The cervical lymph node showed effaced architecture and a sheetlike proliferation of dyscohesive cells with extracapsular extension.