Dyschromatosis symmetrica hereditaria (DSH), also known as acropigmentation of Dohi, was first described by Toyama in 1910 as an unknown hyperpigmentation disorder of the distal extremities .
Dyschromatosis universalis hereditaria (DUH) is a rare genodermatosis first reported by Toyama in 1929 and subsequently by Ichikawa and Hiraga in 1933 .
Toyama, "Dyschromatosis symmetrica hereditaria," Jpn J Dermatol, vol.
Danielo, "Dyschromatosis symmetrica hereditaria: Report of a sporadic case," International Journal of Dermatology, vol.
Dyschromatosis universalis hereditaria (DUH) is a rare genodermatosis reported initially and mostly in Japan.
It comprises of a spectrum of diseases which include dyschromatosis universalis hereditaria (DUH) or acropigmentation of Dohi and segmental form called unilateral dermatomal pigmentary dermatosis (UDPD).1,2,3 Dyschromatosis symmetrica hereditaria (DSH) was first reported as a clinical entity by Toyama in 1929.4 It is characterized by symmetrical distribution of hyperpigmented and hypopigmented macules on the extremities more so over the dorsum of hands and feet.
The differential diagnoses of generalized RPD are dyschromatosis universalis hereditaria (DUH), dermatopathia pigmentosa reticularis (DPR), Naegeli- Franceschetti-Jadassohn syndrome and dyskeratosis congenita (DKC).1,2,3 DUH was first described in 1929 by Toyamo,4a rare clinically heterogeneous genodermatosis characterized by both hyper and hypopigmented macules forming a reticulate pattern.1
Dyschromatosis universalis hereditaria (DUH) and dyschromatosis symmetrica hereditaria are two major types.
[sup] Dyschromatosis universalis hereditaria (DUH; Online Mendelian Inheritance in Man [OMIM] 127500, 615402 and 612715) and dyschromatosis symmetrica hereditaria (DSH; OMIM 127400) are two classic forms of dyschromatoses.
Novel mutations of ABCB6 associated with autosomal dominant dyschromatosis universalis hereditaria.
There is an increase in the number of mitoses, and dyskaryosis, anisokaryosis, and dyschromatosis
are present (figure 3).
Besides ACD, there are many other diseases with the characteristics of cutaneous dyschromia, includes dyschromatosis
universalis hereditaria, xeroderma pigmentosum and poikiloderma-like amyloidosis.