dynorphin


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dy·nor·phin

(dī'nōr-fin),
An endogenous opioid ligand that acts as an agonist at opiate receptors. Extremely potent, widely distributed neuropeptide that has 17 amino acid residues and contains leu5-enkephalin as its NH2-terminal sequence.

dynorphin

/dy·nor·phin/ (di-nor´fin) any of a family of opioid peptides found throughout the central and peripheral nervous systems; most are agonists at opioid receptor sites. Some are probably involved in pain regulation and others in the hypothalamic regulation of eating and drinking.

dynorphin

[dīnôr′fən]
an endogenous opioid derived from the prohormone prodynorphin. It is a neuroactive peptide with potent analgesic effects.

dynorphin

(dī-nŏr′fĭn)
An opiate-like chemical found in the brain, which blocks transmission of pain signals along nerve fibers.
References in periodicals archive ?
In addition, research showed that Lin28b induced dynorphin (DYN) synthesis and that alcohol stimulated DYN release (Srivastava et al.
21,22) Dynorphin was shown to suppress withdrawal syndrome in heroin-dependent humans (23) and morphine-dependent animals through the [ALEPH]-opioid receptors in the spinal cord.
And the dynorphins interact selectively with the kappa opioid receptor (Gianoulakis, 1993).
Rostrocaudal subregional differences in the response of enkephalin, dynorphin and substance P synthesis in rat nucleus accumbens to dopamine depletion.
Dynorphin is an endogenous opioid peptide with a high affinity for the kappa-opioid receptor and its up-regulation in the spinal cord coincide whit an elevation in pain thresholds in rats during pregnancy and parturition (BRADSHAW et al.
Among the neurotransmitters that affect the release of gonadal secretions are endogenous opioid peptides like enkephalin, dynorphin, beta endorphins etc.
Striatal enkephalin and dynorphin opioid systems mediate reward and negative affect, respectively, and are relevant to addiction disorders.
TENS has resulted in increased levels of Y-amino-butyric acid (GABA), endorphin, encephalin and dynorphin in spinal cord (41,42).
37) Other neuroendocrine substances and structures involved include, but not limited to, serotonin, norepinephrine, N-methyl-D-aspartate receptors, opioid peptide receptors, [gamma]-Aminobutyric acid (GABA) systems, dynorphin, acetylcholine, corticotrophin releasing factor, adrenocorticotropic hormone, and corticosterone.
Thus, deregulation of noradrenaline, dynorphin, vasopressin, orexin, and substance P all appear to play a role in alcohol dependence (Koob 2008).
Immunoreactivity to dynorphin, an endogenous opioid, is also increased in regions of histopathologic damage, and decreased blood flow in rat brain following fluid-percussion TBI [48].
Kisspeptin neurons in the arcuate nucleus of the ewe express both dynorphin A and neurokinin B.