dynein


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dynein

 [di´ne-in]
a protein from the microtubules of cilia and flagella, which functions as an ATP-splitting enzyme and is essential to the motility of cilia and flagella.

dyn·ein

(dīn'ēn),
A protein associated with motile structures that exhibits adenosine triphosphatase activity; it forms "arms" on the outer microtubules of cilia and flagella. It functions as a molecular motor.
See also: tubulin, dynein arm.
[dyne + protein]

dynein

(dī′nēn′, -nē-ĭn)
n.
Any of a group of motor proteins that move along microtubules and are involved in intracellular transport of organelles and movement of cilia and flagella.

dyn·ein

(dīn'ēn)
A protein associated with motile structures, exhibiting adenosine triphosphatase activity; it forms "arms" on the outer tubules of cilia and flagella.
See also: tubulin
References in periodicals archive ?
Mice deficient in the axonemal protein Tektin-t exhibit male infertility and immotilecilium syndrome due to impaired inner arm dynein function.
The bright aggregation of actin may form after actin disassembly and accumulation on microtubules by the dynein astral force.
DNHD1 (DYNC1H1) is a member of the dynein heavy chain family and is highly expressed in the brain.
Axonemal beta heavy chain dynein dnah9: Cdna sequence, genomic structure, and investigation of its role in primary ciliary dyskinesia.
In August, Avon scientists announced what they called an "anti-aging breakthrough," saying they had solved "a key piece of the skin-aging puzzle." The team of researchers focused on a transporter protein called dynein, which plays a critical role in carrying nutrients as well as mitochondria, the "powerhouses" within cells, to where they are needed, keeping skin cells productive and functioning optimally.
The subsequent cAMP-dependent phosphorylation of axonemal proteins and dynein light chain triggers the movement of the flagellum (Hayashi et al., 1987; Inaba et al., 1999).
[sup][4] Pedersen and Mygind suggested that this immotility was caused by an abnormal structure of the axonema, consisting of the absence of dynein arms.
It is associated with mutations in genes, mainly affecting DNAI1 on 17 chromosome 9p21-p13, DNAI2, DNAH5 14 chromosome 5p15p14, DNAH11 on 18 chromosome 7p21, thioredoxin domain containing 3 (TXNDC3), radial spoke head 9 homologue (RSPH9) and 4 homologue A (RSPH4A), which results in numerous defects including structural abnormalities of the dynein arms, radial spokes, and microtubules of the cilia.2,6,7
The disorders are characterized by ultrastructural defects in proteins in the outer or inner dynein arms of the ciliary unit.