durable response


Also found in: Dictionary, Thesaurus, Legal, Encyclopedia.

durable response

In cancer care, a long-lasting positive reaction to tumor therapy, usually lasting at least a year.
See also: response
References in periodicals archive ?
The dramatic and durable response occurred by taking targeted therapy or immunotherapy but not by taking chemotherapy.
Despite the promising developments, the strongest and most durable immune responses do not last long, as resistance eventually develops and the more durable responses only occur in a small subset of patients.
The data supporting the FDA approval show that TREANDA is effective, has a tolerable side effect profile in patients with indolent NHL and that treatment results in a high durable response rate.
*At six months, 61% of patients treated with Prochymal still had a durable response requiring no additional immunosuppressive therapy, clinical intervention, or increased steroid use.
Overall response 20.8% 7.2% 0.002 Durable response 10.7% 2.4% 0.007 Progression-free survival, median 3.6 mos.
In a large phase III trial involving 771 patients with unresectable stage III or stage IV melanoma who were randomized to DTIC plus oblimersen or DTIC alone, the combination resulted in significantly better rates of overall response, complete response, durable response lasting more than 6 months, and progression-flee survival (J.
With the durable response rate at 6 months, we can look forward to the fast expedition of the drug on the market."
"The durable response demonstrated by TNX-355 plus OBR, compared to OBR alone in this patient population, indicates that TNX-355 could be a valuable therapy for patients who are faced with limited treatment options."
No patient who had a durable response to the vaccine experienced a recurrence of breast cancer over a median follow-up of 18 months, Lt.
Several clinical case studies have reported durable response suppression following a DRO procedure (e.g., McKeegan, Estill, & Campbell, 1987; Sisson, Van Hasselt, Hersen, & Aurand, 1988; Smith, 1987; Vollmer, Iwata, Smith, & Rodgers, 1992).
It is also possible that isotretinoin alters the gut microflora in such a way that the gut-brain-skin axis fosters a durable response.
Our patient's durable response to anti-PD-1 therapy with minimal side effects is impressive given his history of rheumatoid arthritis and prior high-grade irAE.