ductal intraepithelial neoplasia

Pathology A range of preneoplasia that arises in the ductal epithelium of the breast; the DIN schema is intended to standardize the language used by various pathologists, restricting the term carcinoma to those neoplasms that have extended beyond the ductal basement membrane. Cf Breast cancer, Cervical intraepithelial neoplasia.

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Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia.

Classification, Morphology, Molecular Pathogenesis, and Outcome of Premalignant Lesions of the Pancreas

It is surprising, however, that after more than a hundred years of examining the morphology of breast lesions through the microscope and despite lucid description of the earliest morphologically recognizable neoplastic alterations in the breast several decades ago (5) the lesion now recognized as flat ductal intraepithelial neoplasia 1 or flat epithelial atypia was totally ignored until recently.

Dr Farid Moinfar provides a detailed review of the flat ductal intraepithelial neoplasia 1 (flat epithelial atypia), a lesion beautifully described by Azzopardi5 in 1979.

Challenges in breast pathology: new twists on old problems

Meanwhile, several investigators have found association of tubular carcinoma, as well as lobular intraepithelial neoplasia (LIN), with clinging pattern in breast biopsies (7-10) and have published this distinct morphologic change under a variety of terms such as atypical cystic lobules, (11,12) atypical lobules type A, (13) atypical cystic duct, (14,15) columnar cell change with atypia, (16-18) columnar alteration with prominent apical snouts and secretion, (19-21) columnar cell hyperplasia (with or without atypia), (22-25) small ectatic ducts lined by atypical cells with apocrine snouts, (26) ductal intraepithelial neoplasia (DIN), flat type, (2,6,27) flat epithelial atypia, (16,28-30) and enlarged lobular units with columnar alteration.

Assessment of lesions coexisting with various grades of ductal intraepithelial neoplasia of the breast.

Flat ductal intraepithelial neoplasia of the breast: a review of diagnostic criteria, differential diagnoses, molecular-genetic findings, and clinical relevance--it is time to appreciate the Azzopardi concept!

38,64,65) Bratthauer et al (64) reported that CK903 demonstrated a perinuclear cytoplasmic staining pattern in 100% (40 of 40) of the classic lobular intraepithelial neoplasias (atypical lobular hyperplasia and LCIS) and, in contrast, was negative in all 20 cases (100%) of classic ductal intraepithelial neoplasias (atypical ductal hyperplasia [ADH] and DCIS).