ductal intraepithelial neoplasia

ductal intraepithelial neoplasia

Pathology A range of preneoplasia that arises in the ductal epithelium of the breast; the DIN schema is intended to standardize the language used by various pathologists, restricting the term carcinoma to those neoplasms that have extended beyond the ductal basement membrane. Cf Breast cancer, Cervical intraepithelial neoplasia.
References in periodicals archive ?
Ductal intraepithelial neoplasia was described in a large number of cases, in some of them in direct connection with the UCOGC [24, 35].
Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia. Proc Natl Acad Sci U S A.
It is surprising, however, that after more than a hundred years of examining the morphology of breast lesions through the microscope and despite lucid description of the earliest morphologically recognizable neoplastic alterations in the breast several decades ago (5) the lesion now recognized as flat ductal intraepithelial neoplasia 1 or flat epithelial atypia was totally ignored until recently.
(38,64,65) Bratthauer et al (64) reported that CK903 demonstrated a perinuclear cytoplasmic staining pattern in 100% (40 of 40) of the classic lobular intraepithelial neoplasias (atypical lobular hyperplasia and LCIS) and, in contrast, was negative in all 20 cases (100%) of classic ductal intraepithelial neoplasias (atypical ductal hyperplasia [ADH] and DCIS).